Results 91 to 100 of about 300,331 (272)

Recent Utilization of Pediatric Extrapolation and Modeling and Simulation Approaches in Pediatric Drug Development in Japan

The Journal of Clinical Pharmacology, EarlyView.
Abstract In Japan, the percentage of approved drugs with pediatric indications increased to 30% in 2010‐2015, but no further increase was observed through 2020. The Ministry of Health, Labor, and Welfare in Japan presented draft future directions to promote pediatric drug development, where the modeling and simulation (M&S) approach was introduced as a
Akinori Nakashima, Akihide Tsujimoto, Masako Saito, Jun Takeda, Makiko Natori, Satoshi Shoji   +5 more
wiley   +1 more source

Exploring content and psychometric validity of newly developed assessment tools for itch and skin pain in atopic dermatitis. [PDF]

, 2019
BackgroundAtopic dermatitis (AD) is a common skin disorder characterized by chronic inflammation, altered skin barrier function, and inflammatory cell skin infiltration that decreases health-related quality of life (HRQoL).
Abetz-Webb, Linda, DeLozier, Amy M, Eichenfield, Lawrence F, Gable, Jonathon C, Griffiths, Philip C, Hill, Jennifer N, Hudgens, Stacie, Newton, Louise, Paik, Jim, Silverberg, Jonathan I, Symonds, Tara, Wyrwich, Kathleen W   +11 more
core  

The future outlook on allergen immunotherapy in children: 2018 and beyond. [PDF]

, 2018
Allergen immunotherapy (AIT) is the only currently available immune-modifying and aetiological treatment for patients suffering from IgE-mediated diseases.
Arasi S, Corsello G, Pajno GB, Villani A
core   +2 more sources

Pathophysiology of atopic dermatitis: Clinical implications.

Allergy and Asthma Proceedings, 2019
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. Genetic predisposition, epidermal barrier disruption, and dysregulation of the immune system are some of the critical components of AD.
Jihyun Kim, B. Kim, D. Leung
semanticscholar   +1 more source

Prescription and application adequacy of topical corticosteroids based on the finger‐tip unit method in adult patients with atopic dermatitis: A cross‐sectional study

Journal of General and Family Medicine, EarlyView.
A survey of atopic dermatitis patients at community pharmacies revealed that over one‐third had insufficient topical corticosteroid prescriptions and applications based on the Finger‐Tip Unit method. Prescription insufficiency was associated with application insufficiency.
Fumi Matsuki, Sumire Suzuki, Takashi Hirose, Tatsuhiko Suzuki, Takahito Yoshida, Yoshihiro Onishi, Ryohei Yamamoto   +6 more
wiley   +1 more source

Interplay of Staphylococcal and Host Proteases Promotes Skin Barrier Disruption in Netherton Syndrome. [PDF]

, 2020
Netherton syndrome (NS) is a monogenic skin disease resulting from loss of function of lymphoepithelial Kazal-type-related protease inhibitor (LEKTI-1).
Butcher, Anna M, Cau, Laura, Dupont, Christopher L, Gallo, Richard L, Horswill, Alexander R, Hovnanian, Alain, Kaul, Drishti, Khalil, Shadi, Sanford, James A, Wang, Yichen, Williams, Michael R, Zaramela, Livia S, Zengler, Karsten   +12 more
core  

The measurement of health-related quality of life (QOL) in paediatric clinical trials: a systematic review [PDF]

, 2004
Background The goal of much care in chronic childhood illness is to improve quality of life (QOL). However, surveys suggest QOL measures are not routinely included.
Clarke, S., Eiser, C.
core   +3 more sources

Pediatric autoimmune gastritis: An international, multicentric study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Autoimmune gastritis (AIG) has been poorly described in childhood. We sought to identify the patterns of manifestations of pediatric AIG at onset and to describe its laboratory, clinical, and histopathological features. Methods This was a retrospective, longitudinal, multicenter, cohort study enrolling histologically proven AIG ...
Marco Vincenzo Lenti, Shamim Joudaki, Emanuela Miceli, Edith Lahner, Sara Massironi, Martina Votto, Amelia Licari, Silvia Maria Elena Caimmi, Matteo Bramuzzo, Grazia Di Leo, Marco Crocco, Federica Malerba, Ruggiero Francavilla, Paolo Lionetti, Patrizia Alvisi, Roberto Panceri, Giovanna Zuin, Vincenzo Villanacci, Jacopo Barp, Maurizio Fuoti, Salvatore Oliva, Marina Aloi, Manuela Distante, Amit Assa, Yogev Dotan, Arnaldo Amato, Claudio Romano, Annamaria Staiano, Erasmo Miele, Caterina Strisciuglio, Maria Teresa Fioretti, Fabiana Zingone, Mara Cananzi, Costantino De Giacomo, Giovanni Di Nardo, Andrea Quadrelli, Alessandro Vanoli, Marco Paulli, Bruno Annibale, Gianluigi Marseglia, Antonio Di Sabatino   +40 more
wiley   +1 more source

Isolated lip dermatitis (atopic cheilitis), successfully treated with topical tacrolimus 0.03. [PDF]

Med Oral Patol Oral Cir Bucal, 2021
Georgakopoulou E, Loumou P, Grigoraki A, Panagiotopoulos A.   +3 more
europepmc   +1 more source

Symptoms of egg yolk‐associated food protein‐induced enterocolitis syndrome appear following prolonged cessation

JPGN Reports, EarlyView.
Abstract Food protein‐induced enterocolitis syndrome (FPIES) is a nonimmunoglobulin E (IgE)‐mediated food allergy. Most patients with solid FPIES experience a period of asymptomatic intake of the causative foods before onset. This study aimed to elucidate the pattern of egg yolk (EY) ingestion that triggers FPIES.
Yuka Okura, Masaaki Shimomura, Yutaka Takahashi, Ichiro Kobayashi   +3 more
wiley   +1 more source