Results 51 to 60 of about 38,153 (235)

Molecular mechanisms in idiopathic inflammatory myopathies [PDF]

, 2014
Background: Myositis is a group of rare autoimmune diseases. Muscle weakness and fatigue are the dominant symptoms and inflammation with T cells and macrophages is a characteristic finding in muscle tissue.
Zong, Mei
core   +1 more source

Recalcitrant Dermatomyositis Treated With Anifrolumab

ACR Open Rheumatology
Dermatomyositis is an idiopathic inflammatory myopathy which can present with distinctive skin features. Despite the many treatment modalities for the treatment of dermatomyositis some patients remain refractory to treatment.
Shivang Chaudhary, Meghan Baumer, Laura Upton, Samantha Ong, Kristin Smith, Daniel West, Adam Kilian   +6 more
doaj   +1 more source

Amyopathic Dermatomyositis Associated with Histopathological Findings of Organizing Pneumonia and Pulmonary Vasculitis

Balkan Medical Journal, 2017
Background: Clinically, amyopathic dermatomyositis is a clinically distinct subgroup of dermatomyositis characterised by unique dermatological manifestations without muscle involvement. Clinically, amyopathic dermatomyositis is frequently associated with
Jeong Uk Lim, Hye Seon Kang, Yong Hyun Kim, Tae-Jung Kim   +3 more
doaj   +1 more source

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Advanced Science, EarlyView.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu, Rongrong Wu, Zhicheng Liu, Hongyu Yan, Huan Zhang, Yuanyi Zheng, Xiaojun Cai   +6 more
wiley   +1 more source

Dermatomyositis as paraneoplastic syndrome of peritoneal and ovarian relapse after long-term complete remission in patient with metastatic bilateral breast cancer [Dermatomiozitis kao paraneoplastički sindrom peritonealnog i ovarijalnog relapsa nakon dugog perioda potpune remisije u bolesnice s metastatskim bilateralnim rakom dojke] [PDF]

, 2012
Dermatomyositis is a rare disease characterised by inflammatory muscle affection and characteristic cutaneous changes. When occuring in a patient with cancer, dermatomyositis may indicate recurrence or progression and poor outcome.
Bolanča, Ante, Camino-Varela, Adriana-Maria, Kirac, Iva, Kusić, Zvonko, Murgić, Jure, Prpić, Marin   +5 more
core  

Anti-nuclear matrix protein 2 antibody-associated juvenile dermatomyositis with gastrointestinal perforations was successfully treated with traditional therapeutic drugs combined with vedolizumab: a case report after a long-term follow-up and a review of the literature

Frontiers in Pediatrics
Gastrointestinal perforation in patients with juvenile dermatomyositis has been reported as a life-threatening complication in the literature. However, effective treatment of juvenile dermatomyositis with gastrointestinal perforation remains challenging.
Xue-mei Xu, Shuang Ye, Ying-ying Jin, Chen-xi Liu, Sheng-fang Bao, Hua Huang, Fei Ding, Zhen Yang, Yan-liang Jin   +8 more
doaj   +1 more source

CORRELATIONS BETWEEN NAILFOLD CAPILLAROSCOPY FINDINGS AND DISTINCT CLINICAL FORMS OF JUVENILE DERMATOMYOSITIS [PDF]

Romanian Journal of Rheumatology, 2019
Juvenile dermatomyositis is the most common idiopathic inflammatory myopathy in childhood. Nailfold capillaroscopy plays an important role in its assessment, being useful for diagnosis and follow-up.
Sigrid Covaci, Oana-Maria Farkas, Alexis-Virgil Cochino   +2 more
doaj   +1 more source

Investigating the Role of Type I Interferon Signaling on Muscle Disease Using Mouse Models

Arthritis &Rheumatology, EarlyView.
Objective Dysregulated type I interferon (IFN) signaling contributes to autoimmune myositis pathogenesis. We investigated the therapeutic effects of JAK inhibitors in two mouse models. We also examined how type I IFNs affect muscle vasculature. Methods Myositis was induced in major histocompatibility complex class I double transgenic ([TRE‐H‐2Kb (H ...
Rita Spathis, Sabrina Narvesen, Deeva Robles Kuriplach, Karen Huang, Teja Sundar, Elizabeth Bagley, Joanna Parkes, Xinyu Jia, Nandhana Sudhan, Alfredo Guzman, Kanneboyina Nagaraju, Melissa Morales   +11 more
wiley   +1 more source

Polymyositis And Dermatomyositis - Inflammation, Muscle Structure & Immunosuppressive Treatment [PDF]

, 2012
Polymyositis and dermatomyositis are chronic, inflammatory disorders characterized by muscle weakness, low muscle endurance and by inflammation in skeletal muscle tissues.
Loell, Ingela
core   +1 more source

Dermatomyositis following resection of thyroid and breast cancer: a case report and literature review

Frontiers in Oncology
BackgroundDermatomyositis is an idiopathic inflammatory myopathy and occurs as a paraneoplastic syndrome. Here, we report an unusual case of dermatomyositis that developed in a patient after the resection of thyroid cancer and breast cancer.
Miaomiao Yang, Jiannan Liu
doaj   +1 more source