Results 31 to 40 of about 43,358 (290)

ADIPOQ regulates lipid metabolism by activating AMPK/CPT-1 pathway to attenuate the proliferation of psoriasis lesions

Scientific Reports
Psoriasis is an immune-mediated chronic inflammatory skin disease, with over 100 million people affected worldwide. This disease is accompanied by significant lipid metabolism disorders, affecting the circulatory system and skin tissue.
Jianxiao Xing, Jiao Li, Aihong Peng, Ying Wang, Yuanjun Yao, Yali He, Junqin Li, Kaiming Zhang   +7 more
doaj   +1 more source

Apremilast in the treatment of pityriasis lichenoides et varioliformis acuta: a case report

Journal of Dermatological Treatment
Objectives To evaluate the efficacy and safety of apremilast, a phosphodiesterase-4 (PDE-4) inhibitor, in treating pityriasis lichenoides et varioliformis acuta (PLEVA) and explore its potential mechanisms.Methods We present a 16-year-old male with ...
Jing Zhou, Ming Jing, Ming Liu, Liya Fang, Luan Yang, Guizhi Qiao   +5 more
doaj   +1 more source

OGFRL1 Deficiency Causes Chronic Recurrent Multifocal Osteomyelitis Via Pathologic Osteoclastogenesis, With Therapeutic Response to Tumor Necrosis Factor Inhibitor

Arthritis &Rheumatology, EarlyView.
Objective To verify the pathogenesis of the opioid growth factor receptor like‐1 (OGFRL1) loss‐of‐function variant (c.30del, p. F10Ffs*110) identified in a patient with chronic recurrent multifocal osteomyelitis (CRMO) and to investigate the underlying mechanism.
Wen Xiong, Yusha Wang, Tingyan He, Jinjian Fu, Ying Luo, Jinbo Wang, Jun Wang, Xiaomin Yu, Qing Zhou, Jun Yang   +9 more
wiley   +1 more source

Crotonylation deficiency of S100A7 K49 promotes psoriatic keratinocyte proliferation through enhanced interaction with RAGE

Scientific Reports
Psoriasis is a chronic inflammatory dermatosis characterized by the hyperproliferative of keratinocytes. S100A7 plays a pivotal role in the pathogenesis of psoriasis.
Huifang Liang, Ying Wang, Junqin Li, Kaiming Zhang   +3 more
doaj   +1 more source

Surgical Reconstruction in Pyoderma Gangrenosum, a Retrospective Study of Five Patients

JEADV Clinical Practice, EarlyView.
ABSTRACT Pyoderma Gangrenosum (PG) is a neutrophilic dermatosis characterized by chronic painful ulcerations most commonly on the lower extremities. Current treatment options for PG are largely nonsurgical and include the use of systemic and topical immunomodulators and wound care.
Max E. Oscherwitz, Alysia B. Kohrs, Jacob C. Maus, Matthew L. Hrin, Maria C. Mariencheck, Joseph L. Jorizzo, Kyle E. Robinson, Joseph A. Molnar, Lindsay C. Strowd   +8 more
wiley   +1 more source

Eosinophilic dermatosis of hematologic malignancy mimicking varicella zoster infection: report in a woman with chronic lymphocytic leukemia and review of the literature

Dermatology Practical & Conceptual, 2017
Eosinophilic dermatosis of hematologic malignancy is a rare papulovesicular eruption that presents in patients with hematoproliferative disorders, particularly chronic lymphocytic leukemia.
Omar Bari, Philip R. Cohen
doaj   +1 more source

Extensive abdominal postsurgical Pyoderma Gangrenosum

Clinical Case Reports, 2022
We highlight the key aspects for the diagnosis of Postoperative pyoderma gangrenosum: “Pathergy phenomenon” at surgical site incisions; “Skip lesions”: central venous catheter site lesions were similar to abdominal wall lesions despite distance between ...
Raquel Lalanda
doaj   +1 more source

Pyoderma gangrenosum: current state of the problem

Consilium Medicum, 2021
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that presents with rapidly developing, painful skin ulcers hallmarked by undermined borders and peripheral erythema.
Uladzimir P. Adaskevich
doaj   +1 more source

Prevalence and Burden of Somatic Symptom Disorder in Atopic Dermatitis and Chronic Pruritus—The Persistent Somatic Symptoms Across Diseases: Pruritus (SOMA.PRU) Study

JEADV Clinical Practice, EarlyView.
In adults with atopic dermatitis and chronic pruritus, the mental comorbidity of Somatic Symptom Disorder is associated with higher average and worst pruritus intensity, higher psychological distress and lower quality of life. Additionally, there were nonsignificant changes in cutaneous nerve fiber densities in skin biopsies.
Stefan M. Kahnert, Ansgar Koechel, Gina L. Frank, Svenja Royeck, Claudia Zeidler, Felix Witte, Christian Mess, Konstantin Agelopoulos, Volker Huck, Bernd Löwe, Rupert Conrad, Gudrun Schneider, Stefan W. Schneider, Sonja Ständer   +13 more
wiley   +1 more source

Acute toxicity study of Dermabin

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
The problem of improving the therapy of patients with psoriasis and psoriatic arthritis still remains to be one of the most pressing in the up-to-date dermatology, despite a considerable number of the available and newly appeared medications.
V. L. Karbovskyy, I. A. Shevchuk, O. V. Kurkina, T. Ye. Makovska   +3 more
doaj   +1 more source