Results 51 to 60 of about 43,358 (290)

Clinical Features and Therapeutic Outcomes in Pyoderma Gangrenosum: A Prospective Cohort Study

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis highly associated with systemic comorbidities. Accurate diagnosis and treatment remain challenging due to its rarity and clinical mimickers. Objectives To evaluate demographic, clinical features and treatment outcomes in patients referred with suspected PG at a tertiary ...
David Croitoru, Nesrine Brahimi, Haleh Zabihi, Cathryn Sibbald, Kyle Seigel, Delaram Shojaei, Eric McMullen, Afsaneh Alavi, Lily Archaempong, Aaron M. Drucker, Adam Weizman, Kenneth Croitoru, Robert Inman, Vincent Piguet   +13 more
wiley   +1 more source

Screening of key genes related to disulfidptosis in psoriasis based on the analysis of WGCNA

Scientific Reports
Psoriasis features keratinocyte hyperproliferation. This study aimed to identify disulfidptosis-related key genes in psoriasis for potential diagnostic biomarkers or therapeutic targets.
Qingshan Li, Ping Xu, Yongjun Piao, Zhiyi Wang, Chengzhi Lv   +4 more
doaj   +1 more source

Progress in the Diagnosis and Treatment and the Establishment of Care System for Rare Skin Diseases

罕见病研究, 2023
Rare skin diseases are various in kinds facing many challenges and difficulties in diagnosis and treatment. Recently, the diagnosis of rare skin diseases has improved continuously.
LIU Xiaohan, JIN Hongzhong
doaj   +1 more source

Reversal of Canities in a Patient With Frontal Fibrosing Alopecia

JEADV Clinical Practice, EarlyView.
ABSTRACT Frontal fibrosing alopecia (FFA) is a primary lymphocytic cicatricial alopecia, most commonly affecting postmenopausal women, characterized by progressive frontotemporal hairline recession and eyebrow loss. Hair repigmentation (canities reversal) is an extremely rare event, especially in older individuals with long‐standing white hair.
Nicolò Rivetti
wiley   +1 more source

The role of SPRED1 mutation in melanoma

European Journal of Medical Research
Melanoma is a highly malignant tumor, with its initiation and progression tightly linked to the aberrant activation of the MAPK signaling pathway. As a critical negative regulator of the MAPK pathway, SPRED1 frequently exhibits genomic alteration in ...
Hui Hou, Jiao Li, Jianxiao Xing, Ruixia Hou   +3 more
doaj   +1 more source

The regulatory mechanisms and treatment of HDAC6 in immune dysregulation diseases

Frontiers in Immunology
Histone deacetylase 6 (HDAC6) is a class IIb histone deacetylase that contains two catalytic domains and a zinc finger ubiquitin binding domain (ZnF-UBP). The deacetylation function of HDAC6 has been extensively studied with well-characterized substrates
Yanyang Liang, Yanyang Liang, Ying Wang, Ying Wang, Jianxiao Xing, Jianxiao Xing, Junqin Li, Junqin Li, Kaiming Zhang, Kaiming Zhang   +9 more
doaj   +1 more source

Successful Use of Bimekizumab in Refractory Acute Generalised Exanthematous Pustulosis Triggered by Amoxicillin‐Clavulanate

JEADV Clinical Practice, EarlyView.
ABSTRACT Acute generalised exanthematous pustulosis (AGEP) is a rare, acute neutrophilic dermatosis most commonly triggered by drugs, which typically resolves within 2 weeks following withdrawal of the causative agent. Topical and systemic corticosteroids remain the standard treatment.
Alexandra Junge, Charlotte Vogel, Theresa Hempel, Basil Signer, Nikhil Yawalkar, Kristine Heidemeyer   +5 more
wiley   +1 more source

Retrospective analysis of non-tuberculous mycobacterial skin infections: diagnostic accuracy, treatment efficacy, and PCR-based species detection in a Chinese primary care hospital

Journal of Clinical Microbiology
Non-tuberculous mycobacterial (NTM) skin infections present diagnostic and therapeutic challenges in resource-limited primary care settings. This retrospective study evaluated the diagnosis and treatment of NTM skin infections at a primary care hospital ...
Tianyi Xu, Yingjie Zheng, Ruoning Xue, Ruoyu Li, Wen Zhang, Zaihong Sun, Yinggai Song   +6 more
doaj   +1 more source

Radiation induced lichen planus - an uncommon side effect [PDF]

, 2019
Cutaneous lichen planus is classically characterized by violaceous, pruritic, planar papules and plaques, most commonly affecting the extremities. Lichen planus following radiation therapy is extremely rare and lichen planus following radiation therapy ...
Chen, Yi-Chun, Eastham, David V, Hadian, Yasmin, Schulman, Joshua M, Sood, Apra   +4 more
core  

A case of acanthosis nigricans in a HIV-infected patient [PDF]

, 2020
Background: To date, very little information is available concerning the relationship between acanthosis nigricans (AN) and infection with human immunodeficiency virus type 1 (HIV-1).
De Vincentiis, Ludovica, Di Paolo, Marcello, Iacovelli, Alessandra, Mezzaroma, Ivano, Palange, Paolo, Soda, Giuseppe   +5 more
core   +1 more source