Results 61 to 70 of about 412,458 (245)

Prothrombotic Activation of Platelet Pannexin‐1 Channels in Antiphospholipid Syndrome

Arthritis &Rheumatology, EarlyView.
Objective ATP is released from platelets through both degranulation and pannexin‐1 (PANX1) channels. ATP then activates P2X receptors to amplify platelet activation via calcium‐dependent signaling. The objective of this study was to evaluate the role of platelet PANX1 channels in the pathophysiology of antiphospholipid syndrome (APS), an acquired ...
Bruna de Moraes Mazetto Fonseca, Somanathapura K. NaveenKumar, Srilakshmi Yalavarthi, Kavya Sugur, Thalia G. Newman, Claire K. Hoy, Cyrus Sarosh, Jordan K. Schaefer, Ajay Tambralli, Jacqueline A. Madison, Yu Zuo, Fernanda A. Orsi, Michael Holinstat, Jason S. Knight   +13 more
wiley   +1 more source

Penicillin allergy de‐labelling in the critical care unit: Simulations to design an intravenous drug provocation test that mirrors the plasma profile of an enteral challenge

British Journal of Clinical Pharmacology, EarlyView.
The majority of penicillin allergy labels are incorrect and a label of penicillin allergy is associated with worse outcomes and increased use of healthcare services. Penicillin allergy assessment and de‐labelling may be considered in critically ill patients. An oral penicillin challenge is a common component of most penicillin allergy protocols.
Cleodie Swire, Sean Keane, Reya Vinay Shah, Toqa El‐Nahhas, Iao Lei, Salma Alamin, Niall Conlon, Dagan Osborne Lonsdale   +7 more
wiley   +1 more source

Adverse drug reaction and toxicity caused by commonly used antimicrobials in canine practice [PDF]

, 2014
An adverse drug reaction (ADR) is a serious concern for practicing veterinarians and other health professionals, and refers to an unintended, undesired and unexpected response to a drug that negatively affects the patient's health.
Barranco, Dogan, Frazier, Hall, Hsu, James, Miller, Richard, Roychowdhury, Sandhu, Simonin   +10 more
core   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Alemtuzumab preconditioning with tacrolimus monotherapy - The impact of serial monitoring for donor-specific antibody [PDF]

, 2008
BACKGROUND. Antibody preconditioning with tacrolimus monotherapy has allowed many renal allograft recipients to be maintained on spaced weaning. METHODS.
Adriana Zeevi, Alin L. Girnita, Amadeo Marcos, Amit Basu, Calne, Deanna M. Blisard, Edward A. Gray, Girnita, Henkie P. Tan, Kirk, Knechtle, Kowalski, Liise K. Kayler, Mao, Meier-Kriesche, Mizutani, Montgomery, Ngoc L. Thai, Parmjeet S. Randhawa, Pascual, Pei, Ron Shapiro, Shapiro, Shapiro, Shapiro, Starzl, Stuart, Tan, Thomas E. Starzl, Waldmann   +29 more
core   +1 more source

Effects of rituximab dose on hepatitis B reactivation in patients with resolved infection undergoing immunologic incompatible kidney transplantation

Scientific Reports, 2018
Sensitized patients received desensitization therapy with rituximab for kidney transplantation. However, the impact of rituximab dose on hepatitis B virus (HBV) reactivation is unknown.
Juhan Lee, J. Y. Park, D. Kim, J. Lee, B. Kim, M. Kim, Soon Il Kim, Yu Seun Kim, K. Huh   +8 more
semanticscholar   +1 more source

Cetuximab Hypersensitivity in the Setting of Asymptomatic Alpha‐Gal Sensitization

Head &Neck, EarlyView.
ABSTRACT Background Alpha‐gal syndrome is an allergic condition resulting from the bite of the Lonestar tick in the southeastern US that leads to sensitization to mammalian products containing the oligosaccharide galactose‐alpha‐1,3‐galactose (alpha‐gal).
Alexander G. Emerson, Lindsay Mundy, Barbara A. Murphy, Cosby A. Stone   +3 more
wiley   +1 more source

Allergen immunotherapy for IgE-mediated food allergy: a systematic review and meta-analysis [PDF]

, 2017
Background: The European Academy of Allergy and Clinical Immunology (EAACI) is developing Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated Food Allergy.
Dhami, Sangeeta, et al, Nurmatov, Ulugbek   +2 more
core   +1 more source

Polyphenolic Activation of Basophils Explains Alcohol Hypersensitivity in AERD

The Laryngoscope, EarlyView.
The mechanism behind alcohol sensitivity in AERD has not been previously characterized. This study demonstrates the activation of basophils in patients with CRSwNP and AERD by polyphenolic compounds, but not ethanol. Since these compounds can be found in alcoholic beverages in similar frequencies by which they trigger symptoms, this research provides a
Spencer C. Payne, William Eschenbacher, Ryan Stepp, Larry Borish   +3 more
wiley   +1 more source

Barnes Hospital Bulletin [PDF]

, 1973
https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1090/thumbnail ...

core   +1 more source