Results 71 to 80 of about 4,642 (165)

Safety and Clinical Outcomes of High‐ Versus Low‐Dose Oral Peanut Immunotherapy in Polish Children With Peanut Allergy

Acta Paediatrica, EarlyView.
ABSTRACT Aim To compare safety and clinical outcomes of two different oral immunotherapy (OIT) maintenance doses (150 mg vs. 300 mg) of peanut protein in children with peanut allergy. Methods This prospective study enrolled 44 children aged 4–17 years with confirmed peanut allergy.
Klementyna Łyżwa, Magdalena Chojnowska‐Wójtowicz, Wioletta Zagórska, Marek Kulus, Katarzyna Grzela   +4 more
wiley   +1 more source

Egg desensitization is achieved effectively and safely through a low maintenance dose protocol

Journal of Allergy and Clinical Immunology: Global
Background: Egg allergy is a common IgE-mediated food allergy in children. Oral immunotherapy (OIT) reduces allergic reactions via gradual allergen exposure.
Diana Toscano-Rivero, MD, Nofar Kimchi, MD, Wei Zhao, BSc, Jana Abi-Rafeh, BSc, Danbing Ke, PhD, Duncan Lejtenyi, MSc, Liane Beaudette, RN, Christine McCusker, MD, Bruce D. Mazer, MD, Moshe Ben-Shoshan, MD   +9 more
doaj   +1 more source

Three‐Year Post‐Treatment Outcomes Following Cessation of Peanut Oral Immunotherapy: Comparisons by Clinical Allergy Status and Treatment Group

Allergy, EarlyView.
Paxton Loke, Xiaofang Wang, Sophie Rosser, Melanie Lloyd, Sarah E. Ashley, Adriana C. Lozinsky, Julie Burns, Patrick Quinn, Michael D. O'Sullivan, Michael Gold, Francesca Orsini, Mimi L. K. Tang   +11 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Behaviour Support in Dentistry Core Outcomes (BeSiDe‐CO): A Core Outcome Set Development Study

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Objectives To develop a Core Outcome Set suitable for adults and children for use in studies of Dental Behaviour Support (DBS) techniques, including non‐pharmacological DBS, sedation and General Anaesthesia research. Methods Two systematic reviews generated a preliminary list of candidate outcomes that were shared with Key Stakeholders (KSG ...
Caoimhin Mac Giolla Phadraig, Isabel C. Olegário, Shaelynn Hsu, Maryam Al Zayer, Aisyah Binti Ahmad Fisal, Alison Dougall, Gareth B. Kitchen, Henry F. Duncan, Sarah Baker, Sharat Pani, Sreekanth Kumar Mallineni, Mandy Daly, The BeSiDe COS Collaboration, Tracey Scott, Carolyn Akintola, Éilish Burke, Steve Moore, Barbara Vallo, Jacobo Posse Limerese, Karin Alexandra Van Nes, Maiken Bagger, Olive Healy, Andrew Geddis‐Regan   +22 more
wiley   +1 more source

Research Priorities for Children With Food Allergy: A UK James Lind Alliance Priority Setting Partnership

Clinical &Experimental Allergy, EarlyView.
The UK childhood food allergy James Lind Alliance Priority Setting Partnership collaboratively identified the most important research priorities highlighting the breadth of research required to improve the prevention, diagnosis, treatment and broader impacts of food allergy on those directly impacted. These provide a clear, stakeholder‐driven agenda to
Roxanne M. Parslow, Farhad Shokraneh, Sara J. Brown, Mary Feeney, Graham Roberts, Hora Soltani, Joanne Walsh, Amy Dobson, Emma Vaughan, Deborah Marriage, Suzi Holland, Mary Kelly, Holly Shaw, Alicia Kennedy, Eden Byrne, Liliana Jackson, Gail Jackson, Lauren Gluyas, Jonathan Gower, Alyson Huntley, Matthew J. Ridd   +20 more
wiley   +1 more source

Emerging Paediatric Uses of Dupilumab Beyond Approvals

Clinical &Experimental Allergy, EarlyView.
Dupilumab, through IL‐4Rα blockade, shows promising efficacy beyond approved indications in paediatric diseases driven by T2 inflammation. Emerging evidence—mainly from small studies—supports improvements in disease severity and quality of life, highlighting its potential as a targeted, steroid‐sparing therapy while underscoring the need for ...
Simone Foti Randazzese, Anna Calamita, Diletta D'Angelo, Alessia Marseglia, Esther Mesa Lombardero, Sara Pedersoli, Micol Tedeschi, Mara De Amici, Sara Manti, Valeria Brazzelli, Amelia Licari, Gian Luigi Marseglia   +11 more
wiley   +1 more source

Insights from long-term follow-up of patients treated with oral immunotherapy for cow's milk allergy

Einstein (São Paulo)
Objective: To describe the long-term outcomes of patients undergoing oral immunotherapy for cow's milk allergy in a pediatric allergy clinic, focusing on treatment efficacy and adverse reactions over 5 years of follow-up.
Lais Ferreira Lopes Brum, Nayara Maria Furquim Nasser, Glauce Hiromi Yonamine, Thais Costa Lima de Moura, Mayra de Barros Dorna, Antonio Carlos Pastorino, Beni Morgenstern, Ana Paula Moschione Castro   +7 more
doaj   +1 more source

Short‐term welfare assessment of a single ultrasound‐guided adipose tissue aspiration in standing sedated horses

Equine Veterinary Education, EarlyView.
Summary Background Adipose tissue‐derived mesenchymal stem cells (AT‐MSCs) are entering the market of orthobiologics suitable for managing musculoskeletal disorders in horses, due to their accessibility and reparative capacity. Ethical considerations in developing allogeneic products require a low‐morbidity approach to tissue harvest.
A. Nedergaard, K. M. Kalka, C. Lindegaard   +2 more
wiley   +1 more source

Biologics in IgE-mediated food allergy: A systematic review and meta-analysis of interventional studies

World Allergy Organization Journal
Background and aims: IgE-mediated food allergy (FA) is a major healthcare problem, affecting millions of children and adults worldwide. FA management usually involves elimination diets; however, there is increasing interest in alternative strategies that
Ulugbek B. Nurmatov, MSc, MPH, MD, PhD, Lucia Lo Scalzo, MD, Francesca Galletta, MD, Marianna Krasnenkova, MD, PhD, Stefania Arasi, MSc, MD, PhD, Ignacio J. Ansotegui, MD, PhD, Nara Tagiyeva-Milne, MD, MPH, PhD, Alessandro Fiocchi, MD   +7 more
doaj   +1 more source