Results 71 to 80 of about 473,157 (249)

Clinical Experience With Eliglustat in Children With Gaucher Disease Type 1

American Journal of Medical Genetics Part A, EarlyView.
Erika R. Vucko, Allegra Quadri, Rachel E. Hickey, Carly A. Rasmussen, Monika Izdebski, Joel Charrow, Carlos E. Prada   +6 more
wiley   +1 more source

Molecular and genomic advances in breast cancer: A comprehensive review of predictive and therapeutic innovations

Precision Medical Sciences, EarlyView.
Breast cancer subtypes, estrogen receptor‐positive (ER+), HER2‐enriched, and TNBC, are defined by genomic and epigenetic signatures. Multi‐omics profiling, immunotherapy, liquid biopsy, and AI‐driven radiogenomics enable precision medicine. Tools like Oncotype DX and PAM50 support personalized care.
Samina Malik, Arif Malik, Shahzad Ahmad, Hassan Mohsin, Shazia Iqbal   +4 more
wiley   +1 more source

Desensitization for hematopoietic stem cell transplantation: Case report

Brazilian Journal of Transplantation, 2020
Purpose: The presence of anti-human leukocyte antigen (HLA) antibodies has been correlated with graft failure in organ and tissue transplantation, demonstrating the importance of screening for antibodies before transplant.
Tatiana Schnorr Silva, Luciane Beatriz Kern, Ivaine Tais Sauthier Sartor, Mariana Pinto Pereira, Gabriela Oliveira Zavaglia, David Saitovitch, Lisandra Della Costa Rigoni, Claudia Caceres Astigarraga, Jorge Milton Neumann   +8 more
doaj  

Skin as an immune organ and clinical applications of skin-based immunotherapy

World Allergy Organization Journal, 2018
Background The prevalence of food allergy is increasing, and allergen avoidance continues to be the main standard of care. There is a critical need for safe and effective forms of immunotherapy for patients with food allergy as well as other allergic ...
J. Andrew Bird, Mario Sánchez-Borges, Ignacio J. Ansotegui, Motohiro Ebisawa, José Antonio Ortega Martell   +4 more
doaj   +1 more source

Successful kidney transplantation across a positive complement-dependent cytotoxicity crossmatch by using C1q assay-directed, bortezomib-assisted desensitization

Medicine, 2017
Rationale: Human leukocyte antigen (HLA) is the major immunologic barrier in kidney transplantation (KT). Various desensitization protocols to overcome the HLA barrier have increased the opportunity for transplantation in sensitized patients. In addition,
Juhan Lee, Borae G. Park, H. Jeong, Youn Hee Park, S. Kim, B. Kim, Hye Jin Kim, K. Huh, H. Jeong, Yu Seun Kim   +9 more
semanticscholar   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

A prospective cohort study of ultra-rush subcutaneous immunotherapy in dust mite-induced allergic rhinitis

World Allergy Organization Journal
Background: Allergic rhinitis (AR) is a prevalent disease with a considerable global burden. Allergen immunotherapy (AIT) represents the cornerstone causal treatment for AR.
Yishan Xiong, MD, Wenqi Luo, MS, Hao Peng, MS, Li Shen, MS, Zhiqun Huang, MD, Jieqing Yu, MD, Jing Ye, MD, PhD   +6 more
doaj   +1 more source

TRADITIONAL AND CASCADE PLASMAPHERESIS IN ANTIBODY TITERS’ REDUCTION IN RENAL TRANSPLANT RECIPIENTS

Вестник трансплантологии и искусственных органов, 2014
Introduction. One of the current tasks of transplantology is to overcome «graft-host» immune confl ict. Partially this confl ict is caused by the presence of circulating pre-existing antibodies. Highly sensitized patients have a greater risk of rejection
A.V. Vatazin, A.B. Zulkarnayev, R.O. Kantarija, M. Krstich   +3 more
doaj   +1 more source

Enhanced Early Detection of Allergic Rhinitis: A Prospective Study on a Symptom‐Based Predictive Model

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Introduction Allergic rhinitis (AR) and non‐allergic rhinitis (NAR) share overlapping symptoms but differ in pathophysiology and treatment. Current AR diagnosis relies on skin prick testing (SPT) and serum IgE quantification, both of which are complex.
Ke‐Zhang Zhu, Chao He, Si‐Zhe Zhu, Zheng Liu, Ming Zeng   +4 more
wiley   +1 more source

Kinetics of Antibody Responses and Effector Cell Sensitivity After High Dose Birch Extract Nasal Challenge

Allergy, EarlyView.
High‐dose birch‐extract nasal challenge induced synchronous peaks at 4 weeks in serum specific IgE (sIgE) and basophil sensitivity. Mast cell sensitivity via tSPT and sIgG1 and sIgG4 responses peaked later, at 6–8 weeks. Preseasonal allergen exposure attenuated seasonal sIgE increase and prevented further rise in tSPT sensitivity.
N. J. Campion, S. Villazala‐Merino, C. Morgenstern, L. Nemec, V. Stanek, A. Tu, M. Zghaebi, J. Toth, R. Fröschl, T. Perkmann, M. Bastl, K. Gangl, S. Schneider, H. Breiteneder, R. Ristl, M. Focke‐Tejkl, R. Valenta, V. Niederberger‐Leppin, J. Eckl‐Dorna   +18 more
wiley   +1 more source