Results 91 to 100 of about 4,642 (165)

Antiresorptive therapy influence on peri‐implant diseases: Clinical implications and osteoimmunological perspectives

Periodontology 2000, EarlyView.
Abstract Background/Aim Antiresorptive therapy represents a cornerstone in the management of osteoporosis and cancer‐related bone disease through suppression of osteoclast‐mediated bone resorption. As implant therapy becomes more common in aging populations, clinicians increasingly encounter patients receiving these medications, thus making their ...
Emilio A. Cafferata, Frank Schwarz, Reinhard Gruber   +2 more
wiley   +1 more source

From a 1:4096 Baseline to 1:128 on the Day of Transplantation: Challenging the Titer Barrier in ABO-Incompatible Kidney Transplantation

Case Reports in Medicine
ABO-incompatible (ABOi) kidney transplantation protocols universally mandate reducing circulating isoagglutinin titers to ≤ 1:32 on the day of surgery (Day 0) to prevent hyperacute rejection, rendering Day 0 titers ≥ 1:64 a widely accepted ...
Wipada Songwattana, Veerapat Wattanasatja, Punnawit Laungchuaychok, Kornrawee Sawasdichai, Nisarat Rungsawang, Salin Wattanatorn, Gantapong Sainont, Chanchalee Nopparatana, Chayada Wattanaburanon, Thunyatorn Wuttiputhanun, Asada Leelahavanichkul, Natavudh Townamchai, Yingyos Avihingsanon, Suwasin Udomkarnjananun   +13 more
doaj   +1 more source

Association of donor-specific antibodies with adverse outcomes in solid organ transplantation: A systematic review and meta-analysis of 69 studies

Frontiers in Immunology
ImportancePreformed donor-specific antibodies (pre-DSAs) are a significant immunologic barrier in solid organ transplantation (SOT), yet their association with post-transplant outcomes lacks consensus, limiting standardized clinical management ...
Zhong-yu Kang, Xue-ya Han, Chun Liu, Wei Liu, Dai-hong Li   +4 more
doaj   +1 more source

Breakthrough Hemolysis in Paroxysmal Nocturnal Hemoglobinuria: Mechanistic Insights and Management Strategies

Transfusion, EarlyView.
Abstract Background Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell disorder caused by somatic mutations in the PIGA gene, resulting in loss of glycosylphosphatidylinositol (GPI)‐anchored proteins, including the complement regulatory proteins, CD55 and CD59.
Ganesh Raman, Meghana Vivek, Rida Hasan, Siobán Keel, Laura Connelly‐Smith   +4 more
wiley   +1 more source

Characterisation of Allergen Profiles in Commercial Egg Products to Inform Oral Immunotherapy Strategies in Egg Allergy

Clinical &Experimental Allergy, EarlyView.
Elecia B. Johnston, Shaymaviswanathan Karnaneedi, Eva Birosova, Paxton Loke, Adriana Chebar Lozinsky, Lydia Su‐Yin Wong, Agnes Sze‐Yin Leung, Elizabeth Huiwen Tham, Lynette Pei‐Chi Shek, Mimi L. K. Tang, Andreas L. Lopata   +10 more
wiley   +1 more source

Bioassays in Allergy: Technical Characteristics, Limitations, and Pathways to Clinical Implementation—An EAACI Position Paper

Clinical and Translational Allergy, Volume 16, Issue 10, October 2026.
ABSTRACT Bioassays offer functional readouts of immune responses through specific biomarkers, providing mechanistic insight beyond conventional serology. By capturing cellular activation, tissue‐level changes, and molecular signaling, they hold promise for refining allergy diagnosis, risk stratification, and treatment monitoring, contributing to ...
Cagatay Karaaslan, Oscar Palomares, Busra Kilic, Cristobalina Mayorga, Hans Jürgen Hoffmann, Bernadette Eberlein, Edward Knol, Ruben Fernandez‐Santamaria, Joana Vitte, Elena Izquierdo, Cristina Gomez‐Casado, Marina Perez‐Gordo, Araceli Diaz Perales, Maria M. Escribese   +13 more
wiley   +1 more source

Adverse Reactions Identified after Approval of Novel Medicines: Analysis of 339 New Molecular Entities and Therapeutic Biologics

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 1120-1128, October 2026.
Postmarketing safety surveillance data identify safety issues not identified in preapproval clinical trials. We describe the frequency of new safety issues overall and by labeling section and the relationship of the most commonly added safety issues with the cumulative number of prescriptions dispensed via retail pharmacies.
Ellen Pinnow, Brendan Day, Esther H. Zhou, Corinne Woods, Nana Dwumfour, Jenni Y. Lee, Ilynn Bulatao, Sanae Cherkaoui, Manish Kalaria, Sonja Brajovic, Nabila Sadiq, Farideh Sistani, Maggie Lee, Grace Chai, Gerald Dal Pan   +14 more
wiley   +1 more source

Soluble Immune Checkpoints and Anti‐HLA Antibodies in Kidney Transplant Recipients: Associations With Kidney Function

Immunology, Volume 179, Issue 2, Page 269-286, October 2026.
Soluble immune checkpoints, anti‐HLA panel‐reactive antibodies, and kidney function parameters were evaluated to investigate their associations with early graft function. Pre‐transplant patients showed higher levels of sCD25, sPD‐L1, sTIM‐3, Gal‐9, sCD27, and sPD‐L2 than healthy controls, while post‐transplant temporal changes were observed in sCD25 ...
Cemil Pehlivanoğlu, Fırat Demircan, Başak Aru, Süheyla Apaydın, Abdullah Demir, Rabia Tığlı, Gürkan Tellioğlu, Ali Osman Gürol, Gülderen Yanıkkaya Demirel   +8 more
wiley   +1 more source

Impact of Hymenoptera venom allergy and the effects of specific venom immunotherapy on mast cell metabolites in sensitized children

Annals of Agricultural and Environmental Medicine, 2014
introduction and objective. Mast cells (MC) are effector cells during severe systemic reactions (SR) to Hymenoptera stings. Venom specific immunotherapy (VIT) is the treatment of choice for prevention of SR to stings. Tryptase and prostaglandin D[sub]2[
Ewa Cichocka-Jarosz, Marek Sanak, Andrzej Szczeklik , Piotr Brzyski, Jacek J. Pietrzyk   +4 more
doaj  

Effect of Dupilumab on Allergen-Specific IgE Levels and Clinical Tolerance in Patients with Food Allergy: A Systematic Review. [PDF]

Int J Mol Sci
Grześk-Kaczyńska M, Kaczyński S, Kosztulska B, Rydzyńska M, Rosada T, Ukleja-Sokołowska N.   +5 more
europepmc   +1 more source