Results 91 to 100 of about 469,584 (272)

Hypersensitivity to Excipients in Drugs: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Drugs contain active pharmaceutical ingredients and excipients, compounds which enhance the pharmacokinetics, stability and palatability of the pharmaceutical formulation. While most drug hypersensitivity reactions (DHR) are caused by active ingredients, excipients may also be involved.
Lene H. Garvey, Knut Brockow, Annick Barbaud, Charlotte G. Mortz, Gianfranco Calogiuri, Asli Gelincik, Osman O. Yeğit, Alla Nakonechna, Annette Wagner, Rik Schrijvers, Toon Ieven   +10 more
wiley   +1 more source

Desensitization for hematopoietic stem cell transplantation: Case report

Brazilian Journal of Transplantation, 2020
Purpose: The presence of anti-human leukocyte antigen (HLA) antibodies has been correlated with graft failure in organ and tissue transplantation, demonstrating the importance of screening for antibodies before transplant.
Tatiana Schnorr Silva, Luciane Beatriz Kern, Ivaine Tais Sauthier Sartor, Mariana Pinto Pereira, Gabriela Oliveira Zavaglia, David Saitovitch, Lisandra Della Costa Rigoni, Claudia Caceres Astigarraga, Jorge Milton Neumann   +8 more
doaj  

TRADITIONAL AND CASCADE PLASMAPHERESIS IN ANTIBODY TITERS’ REDUCTION IN RENAL TRANSPLANT RECIPIENTS

Вестник трансплантологии и искусственных органов, 2014
Introduction. One of the current tasks of transplantology is to overcome «graft-host» immune confl ict. Partially this confl ict is caused by the presence of circulating pre-existing antibodies. Highly sensitized patients have a greater risk of rejection
A.V. Vatazin, A.B. Zulkarnayev, R.O. Kantarija, M. Krstich   +3 more
doaj   +1 more source

Successful kidney transplantation across a positive complement-dependent cytotoxicity crossmatch by using C1q assay-directed, bortezomib-assisted desensitization

Medicine, 2017
Rationale: Human leukocyte antigen (HLA) is the major immunologic barrier in kidney transplantation (KT). Various desensitization protocols to overcome the HLA barrier have increased the opportunity for transplantation in sensitized patients. In addition,
Juhan Lee, Borae G. Park, H. Jeong, Youn Hee Park, S. Kim, B. Kim, Hye Jin Kim, K. Huh, H. Jeong, Yu Seun Kim   +9 more
semanticscholar   +1 more source

Kinetics of Antibody Responses and Effector Cell Sensitivity After High Dose Birch Extract Nasal Challenge

Allergy, EarlyView.
High‐dose birch‐extract nasal challenge induced synchronous peaks at 4 weeks in serum specific IgE (sIgE) and basophil sensitivity. Mast cell sensitivity via tSPT and sIgG1 and sIgG4 responses peaked later, at 6–8 weeks. Preseasonal allergen exposure attenuated seasonal sIgE increase and prevented further rise in tSPT sensitivity.
N. J. Campion, S. Villazala‐Merino, C. Morgenstern, L. Nemec, V. Stanek, A. Tu, M. Zghaebi, J. Toth, R. Fröschl, T. Perkmann, M. Bastl, K. Gangl, S. Schneider, H. Breiteneder, R. Ristl, M. Focke‐Tejkl, R. Valenta, V. Niederberger‐Leppin, J. Eckl‐Dorna   +18 more
wiley   +1 more source

A prospective cohort study of ultra-rush subcutaneous immunotherapy in dust mite-induced allergic rhinitis

World Allergy Organization Journal
Background: Allergic rhinitis (AR) is a prevalent disease with a considerable global burden. Allergen immunotherapy (AIT) represents the cornerstone causal treatment for AR.
Yishan Xiong, MD, Wenqi Luo, MS, Hao Peng, MS, Li Shen, MS, Zhiqun Huang, MD, Jieqing Yu, MD, Jing Ye, MD, PhD   +6 more
doaj   +1 more source

World allergy organization guidelines for the assessment and management of anaphylaxis [PDF]

, 2011
The illustrated World Allergy Organization (WAO) Anaphylaxis Guidelines were created in response to absence of global guidelines for anaphylaxis. Uniquely, before they were developed, lack of worldwide availability of essentials for the diagnosis and ...
,, Ardusso, Ledit R. F., Bilo, M. Beatrice, El-Gamal, Yehia M., Ledford, Dennis K., Ring, Johannes, Sanchez-Borges, Mario, Senna, Gian Enrico, Sheikh, Aziz, Simons, F. Estelle R., Thong, Bernard Y.   +10 more
core   +2 more sources

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Effectiveness and safety of orally administered immunotherapy for food allergies: a systematic review and meta-analysis [PDF]

, 2013
The aim of using oral and sublingual immunotherapy with food allergies is to enable the safe consumption of foods containing these aller- gens in patients with food allergies.
Deveraux, Graham, Healy, Laura, Nurmatov, Ulugbek, Sheikh, Aziz, Worth, Alison   +4 more
core   +3 more sources

AKR1C3 Binds β‐Trcp to Promote the Degradation of TFRC to Protect Hepatocellular Carcinoma From Ferroptosis

Cancer Science, EarlyView.
In this study, we show that aldo‐keto reductase family 1 member C3 (AKR1C3), a protein highly expressed in ferroptosis resistant hepatocellular carcinoma cells, acts as an enzyme‐independent scaffold protein by promoting the nuclear export of β‐transducin repeat protein (β‐TrCP) and its binding to transferrin receptor (TFRC) in an enzyme‐independent ...
Lei Qi, Jingyi Hua, Di Pan, Wanwan Yang, Geng Tian, Fangyu Ye, Lingxiang Liu, Yuhan Mao, Qinglong Guo, Haopeng Sun, Li Zhao   +10 more
wiley   +1 more source