Results 101 to 110 of about 473,157 (249)

Research Priorities for Children With Food Allergy: A UK James Lind Alliance Priority Setting Partnership

Clinical &Experimental Allergy, EarlyView.
The UK childhood food allergy James Lind Alliance Priority Setting Partnership collaboratively identified the most important research priorities highlighting the breadth of research required to improve the prevention, diagnosis, treatment and broader impacts of food allergy on those directly impacted. These provide a clear, stakeholder‐driven agenda to
Roxanne M. Parslow, Farhad Shokraneh, Sara J. Brown, Mary Feeney, Graham Roberts, Hora Soltani, Joanne Walsh, Amy Dobson, Emma Vaughan, Deborah Marriage, Suzi Holland, Mary Kelly, Holly Shaw, Alicia Kennedy, Eden Byrne, Liliana Jackson, Gail Jackson, Lauren Gluyas, Jonathan Gower, Alyson Huntley, Matthew J. Ridd   +20 more
wiley   +1 more source

Emerging Paediatric Uses of Dupilumab Beyond Approvals

Clinical &Experimental Allergy, EarlyView.
Dupilumab, through IL‐4Rα blockade, shows promising efficacy beyond approved indications in paediatric diseases driven by T2 inflammation. Emerging evidence—mainly from small studies—supports improvements in disease severity and quality of life, highlighting its potential as a targeted, steroid‐sparing therapy while underscoring the need for ...
Simone Foti Randazzese, Anna Calamita, Diletta D'Angelo, Alessia Marseglia, Esther Mesa Lombardero, Sara Pedersoli, Micol Tedeschi, Mara De Amici, Sara Manti, Valeria Brazzelli, Amelia Licari, Gian Luigi Marseglia   +11 more
wiley   +1 more source

Circadian disruption elicits sex‐specific gut microbiota, endocannabinoidome, and lipid mediator responses

The FEBS Journal, EarlyView.
Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki, Timothy D. Niepokny, Tina Khalilzadehsabet, Elizabeth Dumais, Nicolas Flamand, Vincenzo Di Marzo, Eric M. Mintz, Cristoforo Silvestri   +7 more
wiley   +1 more source

Biomarkers Predicting Sustained Unresponsiveness After Oral Immunotherapy in the OPIA Trial

Allergy, EarlyView.
Duan Ni, Gabriela Pinget, Brigitte Santner‐Nanan, Catherine L. Lai, Laurence Macia, Dianne E. Campbell, Peter Hsu, Ralph Nanan   +7 more
wiley   +1 more source

Australian consensus recommendations for the management of increased meningococcal infection risk in adults with neurological diseases treated with complement inhibitors

Internal Medicine Journal, EarlyView.
Abstract Complement inhibitor therapy carries a risk of serious infections, including meningococcal disease. Here we provide evidence‐based recommendations and expert consensus for immunisation and prophylactic treatment of patients receiving, or planning to receive, complement inhibitors for neurological conditions in the Australian setting.
Katherine A. Buzzard, Michael Barnett, Heidi Beadnall, Mirasol Forcadela, Lesley‐Ann Hall, Victoria G. Hall, Todd Hardy, Danny Hsu, Paul Kinsella, Mastura Monif, Sudarshini Ramanathan, Stephen W. Reddel, Sean Riminton, Douglas F. Johnson   +13 more
wiley   +1 more source

Soluble Immune Checkpoints and Anti‐HLA Antibodies in Kidney Transplant Recipients: Associations With Kidney Function

Immunology, EarlyView.
Soluble immune checkpoints, anti‐HLA panel‐reactive antibodies, and kidney function parameters were evaluated to investigate their associations with early graft function. Pre‐transplant patients showed higher levels of sCD25, sPD‐L1, sTIM‐3, Gal‐9, sCD27, and sPD‐L2 than healthy controls, while post‐transplant temporal changes were observed in sCD25 ...
Cemil Pehlivanoğlu, Fırat Demircan, Başak Aru, Süheyla Apaydın, Abdullah Demir, Rabia Tığlı, Gürkan Tellioğlu, Ali Osman Gürol, Gülderen Yanıkkaya Demirel   +8 more
wiley   +1 more source

Pathophysiology and emerging treatments for dermographic, cholinergic and cold urticaria

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review illustrates key proposed mast cell‐mediated activation pathways in dermographic, cholinergic and cold urticaria, highlighting IgE‐dependent and ‐independent mechanisms. These pathways are increasingly targeted by emerging drugs, aiming to interrupt mast cell activation and mediator release, offering more precise, mechanism‐based treatment ...
Mojca Bizjak‐Suran, Matjaž Fležar, Manuel Pedro Pereira   +2 more
wiley   +1 more source

Biologics in IgE-mediated food allergy: A systematic review and meta-analysis of interventional studies

World Allergy Organization Journal
Background and aims: IgE-mediated food allergy (FA) is a major healthcare problem, affecting millions of children and adults worldwide. FA management usually involves elimination diets; however, there is increasing interest in alternative strategies that
Ulugbek B. Nurmatov, MSc, MPH, MD, PhD, Lucia Lo Scalzo, MD, Francesca Galletta, MD, Marianna Krasnenkova, MD, PhD, Stefania Arasi, MSc, MD, PhD, Ignacio J. Ansotegui, MD, PhD, Nara Tagiyeva-Milne, MD, MPH, PhD, Alessandro Fiocchi, MD   +7 more
doaj   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source