Results 141 to 150 of about 141,048 (298)

The role of aspirin desensitization in patients with aspirin-exacerbated respiratory disease (AERD)

Brazilian Journal of Otorhinolaryngology
INTRODUCTION: Aspirin-exacerbated respiratory disease (AERD) consists of a classic tetrad: moderate/severe asthma, chronic rhinosinusitis, nasal polyps, and intolerance to aspirin or other nonsteroidal anti-inflammatory drugs.
Jonas Willian Spies, Fabiana Cardoso Pereira Valera, Daniel Loiola Cordeiro, Taís Nociti de Mendonça, Marcelo Gonçalves Junqueira Leite, Edwin Tamashiro, Luiza Karla Arruda, Wilma Terezinha Anselmo-Lima   +7 more
doaj   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

A Site of Alcohol Action at the NMDA Receptor M3-M4 Domain Interface [PDF]

, 2012
The N-methyl-D-aspartate (NMDA) glutamate receptor is a major target of ethanol in the brain. Previous studies have identified positions in the third and fourth membrane-associated (M) domains of the NMDA receptor GluN1 and GluN2A subunits that influence
Dwyer, D.S, Peoples, Robert W., Ren, Hong, Zhao, Yuanhao   +3 more
core   +1 more source

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

Respirology, EarlyView.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

From ab initio quantum mechanics to molecular neurobiology: A cation-pi binding site in the nicotinic receptor [PDF]

, 1998
The nicotinic acetylcholine receptor is the prototype ligand-gated ion channel. A number of aromatic amino acids have been identified as contributing to the agonist binding site, suggesting that cation-pi interactions may be involved in binding the ...
Dougherty, Dennis A., Gallivan, Justin P., Lester, Henry A., Li, Lintong, Zhang, Yinong, Zhong, Wenge   +5 more
core  

When the mind reprocesses the night: A clinical case study on eye movement desensitization and reprocessing therapy for idiopathic nightmare disorder

Sleep Research, EarlyView.
Abstract Introduction Nightmare Disorder (ND) is a prevalent sleep disorder linked to nocturnal and daytime impairments. Image Rehearsal Therapy (IRT) shows moderate effects, and evidence for other psychological interventions, including eye movement desensitization and reprocessing (EMDR), remains scarce in adults with idiopathic ND (IND). Methods This
Filipa Almeida, Maria Inês Clara, Margarida Rodrigues, Ana Allen Gomes   +3 more
wiley   +1 more source

In Vitro Reconstruction of Axonal Heat Sensing with a Photothermal Nerve‐on‐a‐Chip

Small, EarlyView.
A photothermal nerve‐on‐a‐chip platform is presented that enables precise, localized heating of sensory axons with simultaneous electrical recording. The system reveals millisecond‐scale dynamics of heat‐evoked neural activity and provides a new approach to study how temperature‐dependent ion channel behavior is translated into axonal firing.
Koji Sakai, Yujiro Tanaka, Riku Takahashi, Toichiro Goto, Yosuke Mizuno, Taiki Otomo, Aya Tanaka   +6 more
wiley   +1 more source

Preliminary investigation of equine veterinary hospital staff attitudes towards pain assessment in a single centre

Veterinary Record, EarlyView.
Abstract Background Despite the availability of several equine pain assessment tools, their use in equine veterinary practice appears limited compared to small animal practice. This study explores potential barriers to equine pain assessment, as reported by staff at a single UK equine teaching hospital.
Olivia Curry, Alice Everett, Gemma Pearson, Cathy Dwyer, Juliet Duncan   +4 more
wiley   +1 more source

Clinical characteristics of immediate allergic adverse reactions to intravenous amoxicillin‒clavulanic acid in conscious dogs

Veterinary Record, EarlyView.
Abstract Background Amoxicillin‒clavulanic acid (AMC) is one of the most frequently used antibiotics in small animal practice, and reports on adverse reactions are scarce. The aim of this study was to describe the clinical characteristics of immediate allergic adverse reactions to intravenous (IV) AMC in conscious dogs. Methods The medical records of a
Leonel Frutuoso, Anna Threlfall
wiley   +1 more source

Abattoir antemortem inspection protocol: Observation of unloading improves detection of transport welfare compromises in livestock

Veterinary Record, EarlyView.
Abstract Background Ensuring livestock welfare throughout the production chain, including transport, is an ethical and regulatory imperative. However, protocols to assess transport‐related welfare during routine abattoir inspections are not standardised, including antemortem (AM) inspection by an official veterinarian at UK abattoirs.
Sayaka Mochizuki, Declan Arden, Kurt Arden   +2 more
wiley   +1 more source