Results 121 to 130 of about 141,048 (298)

A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels

eLife, 2019
ASICs are proton-gated sodium channels expressed in neurons. Structures of chicken ASIC1 in three conformations have advanced understanding of proton-mediated gating; however, a molecular mechanism describing desensitization from open and pre-open states
Yangyu Wu, Zhuyuan Chen, Cecilia M Canessa   +2 more
doaj   +1 more source

Transnasal endoscopy for eosinophilic esophagitis surveillance in adolescents with mild autism spectrum disorder: A single‐center case series

JPGN Reports, EarlyView.
Abstract Children with autism spectrum disorder (ASD) often experience sensory sensitivities and procedural anxiety, which can complicate sedated esophagogastroduodenoscopy (EGD). Transnasal endoscopy (TNE) is a less invasive, unsedated alternative, but data on its use in this population are limited.
Natalee Sarintra, Robbie Pesek, Travis Ayers, Christina Tootle, Sulaiman S. Bharwani, Alejandro Ramirez, Hamza Hassan Khan   +6 more
wiley   +1 more source

Pilot Study: Program Evaluation of Peanut Oral Immunotherapy in a Private Clinic [PDF]

, 2019
The privilege of providing a therapy perceived by patients and families as “life changing” has seasoned physicians describing food oral immunotherapy (OIT) as one of “the most impactful and rewarding thing that they have done in medicine” (Wasserman ...
Olson, Kinga
core   +1 more source

Can trigeminal sensations impact saltiness perception? A mini‐review

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Many food companies have begun to reduce the salt content in their products due to health concerns; however, this reduction in salt content can affect the food's sensory appeal and flavour complexity. Flavour is defined as a combination of odour (i.e., smell), taste (i.e., gustation) and trigeminal sensations (i.e., chemesthesis).
Emily Dolan, Nicoletta Faraone, Matthew B McSweeney   +2 more
wiley   +1 more source

Epileptic encephalopathy with spike‐and‐wave activation in sleep associated with Tatton–Brown–Rahman syndrome responsive to highly purified cannabidiol

Epileptic Disorders, EarlyView.
Anita N. Datta
wiley   +1 more source

Testing the factor structure of the International Trauma Questionnaire in a sample of violence‐exposed women living in Northern Ireland

Journal of Traumatic Stress, EarlyView.
Abstract The International Trauma Questionnaire (ITQ) assesses posttraumatic stress disorder (PTSD) and the disturbances in self‐organization (DSO) aspect of complex PTSD (CPTSD) per the ICD‐11. This study examined the ITQ's factor structure among violence‐ or abuse‐exposed women in Northern Ireland, a region with a history of conflict (i.e., “the ...
Marcin Owczarek, Mark Shevlin, Julie‐Ann Jordan, Ngozi Anyadike‐Danes, Claire McCartan, Susan Lagdon   +5 more
wiley   +1 more source

Surprise Marketing

Psychology &Marketing, EarlyView.
ABSTRACT Surprise marketing, characterized by unexpected tactics such as blind boxes and spontaneous discounts, captivates consumers by sparking curiosity and participation. Despite increasing industry use, scholarly research remains fragmented and limited.
Xin‐Jean Lim, Weng Marc Lim, Park Thaichon   +2 more
wiley   +1 more source

Aspirin Desensitization and Percutaneous Coronary Intervention in a Patient with Aspirin Hypersensitivity and Acute Coronary Syndrome: A Case Report

Journal of Nepal Medical Association
Hypersensitivity to aspirin is rare disorder occurring in 1.88% of the patients. Aspirin-hypersensitive patients requiring single antiplatelet agent may be treated with clopidogrel, an alternative antiplatelet agent.
Suman Acharya, Siddinath Gyawali , Sanjeev Kharel, Dinesh Upreti, Khem Raj Bhusal, Silvia Maharjan, Hemanta Shrestha, Ratna Mani Gajurel   +7 more
doaj   +1 more source

Advances in GPCRs Associated With Wnt Signaling Within the Auditory System

Medicine Bulletin, EarlyView.
ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang, Changling Xu, Jiangang Fan, Renjie Chai   +3 more
wiley   +1 more source

Successfully Overcoming Allergy to Anakinra Through Intravenous Desensitization in a Child “Case Report”

Case Reports in Immunology
Anakinra, a recombinant interleukin-1 (IL-1) receptor antagonist, is effective in treating autoinflammatory conditions in children; however, it may elicit a hypersensitive reaction, thus requiring desensitization.
Tariq Al Farsi
doaj   +1 more source