Results 131 to 140 of about 141,048 (298)
Neurourology and Urodynamics, EarlyView.ABSTRACT Aims While many patients with lower urinary tract symptoms (LUTS) improve by treating peripheral causes, a substantial proportion continue to experience symptoms despite apparently successful interventions. Central nervous system (CNS) mechanisms could potentially contribute to persisting symptoms after the initial peripheral cause has been ...
Mathijs M. de Rijk +7 more
wiley +1 more source
Frontiers in PharmacologyBackground: Cystic fibrosis transmembrane conductance regulator modulators are the only available treatment for cystic fibrosis. Although elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) is well-tolerated, rash has been reported as very frequent. In severe
L. Gómez-Ganda +9 more
doaj +1 more source
“What Medical Management Should Be First Line for Bladder Storage Symptoms in NLUTD”—Pro Botox
Neurourology and Urodynamics, EarlyView.ABSTRACT Objectives Neurogenic lower urinary tract dysfunction (NLUTD) severely impairs patient quality of life (QoL). While oral medications are often first‐line treatments, their high failure rates and side effects limit their effectiveness. Thus, we argue for the use of intravesical botulinum toxin A (BoNT‐A) injections as a first‐line alternative ...
Vada Furlan +2 more
wiley +1 more source
Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a [PDF]
, 2008 Acid-sensing ion channels are ligand-gated cation channels, gated by extracellular H+. H+ is the simplest ligand possible, and whereas for larger ligands that gate ion channels complex binding sites in the three-dimensional structure of the proteins have
Chen, Xuanmao +4 more
core +1 more source
Current Status of Kidney Xenotransplantation in Basic Research
Organ Medicine, EarlyView.Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley +1 more source
Desensitization in patients with hypersensitivity to platinum and taxane in gynecological cancers
Cancer MedicineBackground Exposure to paclitaxel and carboplatin has the risk of developing hypersensitivity reactions (HSRs), which could necessitate using less effective treatments to avoid anaphylaxis.
Tibor A. Zwimpfer +6 more
doaj +1 more source
Pediatric Anesthesia, EarlyView.ABSTRACT Background Preoperative anxiety is a significant stressor for children and is associated with negative postoperative outcomes. Although the incidence of difficult inductions during a single anesthetic encounter is well documented, the longitudinal trajectory of anxiety behaviors in children undergoing repeated anesthesia remains poorly ...
Annie Xin +6 more
wiley +1 more source
People and Nature, EarlyView.Abstract Human actions can not only contribute to species extinction but also offer a path towards preventing it. Therefore, it is essential for conservation communicators to identify optimal communication methods to encourage positive pro‐conservation behaviours.
Meghan N. Shaw +4 more
wiley +1 more source
Polymer International, EarlyView.Hybrid jute/carbon epoxy laminates have better mechanical performance and less drilling damage by the use of optimized stacking sequence and machining parameters. Abstract Three composite laminate systems were produced using the standard hand lay‐up method: jute‐fibre‐reinforced polymer (JFRP), carbon‐fibre‐reinforced polymer (CFRP) and a hybrid of the
Paulraj Prabhu +5 more
wiley +1 more source
Precision Medical Sciences, EarlyView.Breast cancer subtypes, estrogen receptor‐positive (ER+), HER2‐enriched, and TNBC, are defined by genomic and epigenetic signatures. Multi‐omics profiling, immunotherapy, liquid biopsy, and AI‐driven radiogenomics enable precision medicine. Tools like Oncotype DX and PAM50 support personalized care.
Samina Malik +4 more
wiley +1 more source