Results 111 to 120 of about 141,048 (298)

Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome

Food Biomacromolecules, EarlyView.
Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley   +1 more source

TRAF6-mediated ubiquitination of AKT in the nucleus is a critical event underlying the desensitization of G protein-coupled receptors

Cell Communication and Signaling
Background Desensitization of G protein–coupled receptors (GPCRs) refers to the attenuation of receptor responsiveness by prolonged or intermittent exposure to agonists.
Chengyan Wu, Li Hu, Bing Liu, Xingyue Zeng, Haixiang Ma, Yongkai Cao, Huijun Li, Xiaohan Zhang   +7 more
doaj   +1 more source

Use of HLA desensitization in the management of renal transplant recipients in Europe

Frontiers in Immunology
A significant challenge in kidney transplantation is overcoming immunological barriers such as human leukocyte antigen (HLA) incompatibilities. The presence of anti-HLA antibodies in the transplant candidate is referred to as HLA sensitization.
Lionel P. E. Rostaing, Georg A. Böhmig, Muhammed Mahdi Taqi, Ben Gibbons   +3 more
doaj   +1 more source

Assessing the Impact of a Positive Psychology School‐Based Psychoeducation on the Mental Health of Adolescents Affected by the 2023 Earthquake in Türkiye

Journal of Adolescence, EarlyView.
ABSTRACT Introduction The purpose of this study is to examine the effectiveness and acceptability of a positive psychology‐based psychoeducation program on the psychological states, future expectations, and coping styles of adolescents affected by the 2023 earthquake in Türkiye. Methods A single‐group, pretest‐posttest design was adopted.
Veysel Kaplan, Mehmet Emin Düken, Abanoub Riad, Muhammad Alkasaby   +3 more
wiley   +1 more source

Two-year follow-up after drug desensitization in mucopolysaccharidosis

Orphanet Journal of Rare Diseases
Background Mucopolysaccharidosis (MPS) type 1 S and type 2 are rare lysosomal storage disorders characterized by impaired enzyme production, resulting in glycosaminoglycans accumulation within lysosomes.
Federico Spataro, Roberto Ria, Nada Chaoul, Antonio Giovanni Solimando, Vanessa Desantis, Angelo Vacca, Danilo Di Bona, Attilio Di Girolamo, Luigi Macchia   +8 more
doaj   +1 more source

Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects. [PDF]

, 2015
Activation of nicotinic acetylcholine receptors (nAChRs) is associated with the binding of agonists such as acetylcholine to an extracellular site that is located at the interface between two adjacent receptor subunits.
D'Oyley, JM, Dhankher, P, Gill-Thind, JK, Millar, NS, Sheppard, TD   +4 more
core  

Adolescents' Experiences of Hate Speech and Psychological Needs: A Reflexive Thematic Analysis

Journal of Adolescence, EarlyView.
ABSTRACT Introduction Adolescents are increasingly exposed to hate speech in both online and offline contexts, yet limited research has examined how such exposure is experienced and how it relates to adolescents' psychological needs and well‐being. Drawing on Self‐Determination Theory (SDT), this study explores how adolescents make sense of hate speech
Tomas Jungert, Camilla Forsberg, Robert Thornberg, Lisa Nordlund, Emelie Hansen, Elisa Lagerstedt, Coralie Levesque   +6 more
wiley   +1 more source

Effects of anti-HLA donor-specific antibodies and desensitization on engraftment of haploidentical hematopoietic stem cell transplantation

陆军军医大学学报
Objective To investigate the effects of anti-HLA donor-specific antibodies (DSA) and desensitization for DSA+patients on engraftment of haploidentical hematopoietic stem cell transplantation (haplo-HSCT). Methods The patients who underwent haplo-HSCT and
MA Yao, ZHANG Yanfang, ZHOU Kang
doaj   +1 more source

Current Orthodontic Education Status on Treating Patients With ASD and/or ADHD in North America

Journal of Dental Education, EarlyView.
ABSTRACT Objectives Autism spectrum disorder (ASD) and attention‐deficit hyperactivity disorder (ADHD) are associated with specific dental and behavioral attributes, particularly in children, that necessitate special attention from healthcare providers.
Nikki Wei, Chun‐Hsi Chung, Ilana Zinn, Mark S. Wolff, Chenshuang Li   +4 more
wiley   +1 more source

Comparative efficacy of novel bioactive glass versus sodium fluoride toothpaste for dentin hypersensitivity

Journal of Periodontology, EarlyView.
Abstract Background This first‐in‐human clinical study aimed to evaluate the safety and efficacy of a bioglass incorporated in a toothpaste, in reducing dentin hypersensitivity (DH) compared to a sodium fluoride (NaF) toothpaste over a 2‐week period. Methods A double‐blind, randomized, parallel‐arm, proof‐of‐concept clinical trial was conducted with 46
Hatice Hasturk, Daniel Boyd, Kathleen MacDonald‐Parsons, Stephanie Turner‐Cahill, Joon Seong, Nicola West, Heather J. Doucette   +6 more
wiley   +1 more source