Results 91 to 100 of about 91,740 (302)

General considerations on rapid desensitization for drug hypersensitivity - a consensus statement

, 2010
Drug hypersensitivity reactions can occur with most drugs, are unpredictable, may affect any organ or system, and range widely in clinical severity from mild pruritus to anaphylaxis. In most cases, the suspected drug is avoided in the future.
Bircher, A., Sanz, M. L., Romano, A., Campi, P., Cernadas, J. R., Aberer, W., Castells, M., Torres, M. J., the EAACI interest group on drug hypersensitivity,, Brockow, K., for the European Network of Drug Allergy,, Pichler, Werner Joseph, Demoly, P.   +12 more
core   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Two-year follow-up after drug desensitization in mucopolysaccharidosis

Orphanet Journal of Rare Diseases
Background Mucopolysaccharidosis (MPS) type 1 S and type 2 are rare lysosomal storage disorders characterized by impaired enzyme production, resulting in glycosaminoglycans accumulation within lysosomes.
Federico Spataro, Roberto Ria, Nada Chaoul, Antonio Giovanni Solimando, Vanessa Desantis, Angelo Vacca, Danilo Di Bona, Attilio Di Girolamo, Luigi Macchia   +8 more
doaj   +1 more source

Aplikasi eye moving desensitization dan reprocessing dalam konseling post-traumatic stress disorder

Teraputik: Jurnal Bimbingan dan Konseling, 2017
Akhir-akhir ini banyak peristiwa yang berpotensi memunculkan efek traumatik yang jika tidak ditangani akan menimbulkan gangguan stres pascatrauma. Olehnya itu, dibutuhkan upaya-upaya untu menangani masalah ini.
Hengki Satrianta
doaj   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

Deferasirox desensitization [PDF]

The Journal of Allergy and Clinical Immunology: In Practice, 2016
Karen E, Bruner, Kevin M, White
openaire   +2 more sources

Antibiotic desensitization in adults with cystic fibrosis

, 2003
Objective: Allergic reactions to antibiotics occur in up to 30% of patients with cystic fibrosis (CF). Repeated antibiotic exposure and immune hyper-responsiveness increase the risk of allergic reactions and may limit antibiotic choice.
Bell, S. C., Burrows, J. A., Toon, M.
core   +1 more source

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

TRAF6-mediated ubiquitination of AKT in the nucleus is a critical event underlying the desensitization of G protein-coupled receptors

Cell Communication and Signaling
Background Desensitization of G protein–coupled receptors (GPCRs) refers to the attenuation of receptor responsiveness by prolonged or intermittent exposure to agonists.
Chengyan Wu, Li Hu, Bing Liu, Xingyue Zeng, Haixiang Ma, Yongkai Cao, Huijun Li, Xiaohan Zhang   +7 more
doaj   +1 more source

Use of HLA desensitization in the management of renal transplant recipients in Europe

Frontiers in Immunology
A significant challenge in kidney transplantation is overcoming immunological barriers such as human leukocyte antigen (HLA) incompatibilities. The presence of anti-HLA antibodies in the transplant candidate is referred to as HLA sensitization.
Lionel P. E. Rostaing, Georg A. Böhmig, Muhammed Mahdi Taqi, Ben Gibbons   +3 more
doaj   +1 more source