Results 71 to 80 of about 67,581 (257)

Cannabidiol reduces atypical absence seizures and epileptic spasms in a Gabrb3+/D120N mouse model of Lennox–Gastaut syndrome

Epilepsia Open, EarlyView.
Abstract Objective Lennox–Gastaut syndrome (LGS) is a drug‐resistant developmental and epileptic encephalopathy (DEE). Preclinical drug development for LGS is constrained by a lack of syndrome‐relevant animal models. We aimed to evaluate a Gabrb3+/D120N knock‐in (KI) mouse model of LGS by quantifying atypical absence seizures and epileptic spasms and ...
Thomas Harman, Laura A. Sharman, Ka Lai Yip, Miguel Bedoya‐Pérez, Vaishali Janve, Jonathon C. Arnold   +5 more
wiley   +1 more source

Effects of anti-HLA donor-specific antibodies and desensitization on engraftment of haploidentical hematopoietic stem cell transplantation

陆军军医大学学报
Objective To investigate the effects of anti-HLA donor-specific antibodies (DSA) and desensitization for DSA+patients on engraftment of haploidentical hematopoietic stem cell transplantation (haplo-HSCT). Methods The patients who underwent haplo-HSCT and
MA Yao, ZHANG Yanfang, ZHOU Kang
doaj   +1 more source

Cheek tooth extraction in geriatric versus non‐geriatric horses

Equine Veterinary Journal, EarlyView.
Abstract Background Age‐related dental changes are major contributors to dental disorders in older horses, and cheek tooth extractions are often required to maintain masticatory function and oral comfort. However, limited information is available on clinical and treatment characteristics in this older patient population.
Elias Mair, Omid Nekouei, Patricia Trummer‐Schug, Rhea Haralambus, Nora Mareike Biermann   +4 more
wiley   +1 more source

Development and Deployment of DeepSeek‐Based Applications in Healthcare: A Chinese Perspective

Health Care Science, EarlyView.
Generative Artificial Intelligence based on DeepSeek drives the comprehensive development of healthcare in China, demonstrating potential application across multiple areas. ABSTRACT Background Artificial intelligence (AI) is already showing enormous potential in the healthcare sector.
Maoxin Lv, Ning Li, Hui Zhang, Chao Liu, Ge Wu, Zheng Zhu, Yao Zhu, Mengchun Gong   +7 more
wiley   +1 more source

Assessing the Impact of a Positive Psychology School‐Based Psychoeducation on the Mental Health of Adolescents Affected by the 2023 Earthquake in Türkiye

Journal of Adolescence, EarlyView.
ABSTRACT Introduction The purpose of this study is to examine the effectiveness and acceptability of a positive psychology‐based psychoeducation program on the psychological states, future expectations, and coping styles of adolescents affected by the 2023 earthquake in Türkiye. Methods A single‐group, pretest‐posttest design was adopted.
Veysel Kaplan, Mehmet Emin Düken, Abanoub Riad, Muhammad Alkasaby   +3 more
wiley   +1 more source

A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels

eLife, 2019
ASICs are proton-gated sodium channels expressed in neurons. Structures of chicken ASIC1 in three conformations have advanced understanding of proton-mediated gating; however, a molecular mechanism describing desensitization from open and pre-open states
Yangyu Wu, Zhuyuan Chen, Cecilia M Canessa   +2 more
doaj   +1 more source

Adolescents' Experiences of Hate Speech and Psychological Needs: A Reflexive Thematic Analysis

Journal of Adolescence, EarlyView.
ABSTRACT Introduction Adolescents are increasingly exposed to hate speech in both online and offline contexts, yet limited research has examined how such exposure is experienced and how it relates to adolescents' psychological needs and well‐being. Drawing on Self‐Determination Theory (SDT), this study explores how adolescents make sense of hate speech
Tomas Jungert, Camilla Forsberg, Robert Thornberg, Lisa Nordlund, Emelie Hansen, Elisa Lagerstedt, Coralie Levesque   +6 more
wiley   +1 more source

Current Orthodontic Education Status on Treating Patients With ASD and/or ADHD in North America

Journal of Dental Education, EarlyView.
ABSTRACT Objectives Autism spectrum disorder (ASD) and attention‐deficit hyperactivity disorder (ADHD) are associated with specific dental and behavioral attributes, particularly in children, that necessitate special attention from healthcare providers.
Nikki Wei, Chun‐Hsi Chung, Ilana Zinn, Mark S. Wolff, Chenshuang Li   +4 more
wiley   +1 more source

Curriculum Guidelines for Social and Behavioral Sciences in Predoctoral Dental Education

Journal of Dental Education, EarlyView.
ABSTRACT Social and behavioral sciences are an integral part of predoctoral dental education, given the important role of social and behavioral factors in oral health, dentist‐patient communication, the provision of person‐centered care, and patients’ experience of dental treatment and their treatment outcomes.
Cameron L. Randall, Casey D. Wright, Dolores Cannella, Jessica G. Hinz, Daniel W. McNeil, Drashty P. Mody, Gary Pape, Yun Saksena, Vaishali Singhal, Lance Brendan Young, Stuart M. Schrader   +10 more
wiley   +1 more source

RECiPROsody: A Study Protocol for Investigating Movement and Prosodic Synchrony as Embodied Markers of Relational Attunement in Gestalt Psychotherapy

The Journal of Humanistic Counseling, EarlyView.
ABSTRACT Nonverbal synchrony supports therapeutic alliance, yet its role in Gestalt psychotherapy remains underexplored. This manuscript presents the RECiPROsody study protocol, designed to investigate how multimodal interpersonal synchrony between therapists and clients relates to embodied attunement and therapeutic outcomes.
Serena Iacono Isidoro, Margherita Spagnuolo Lobb, Simona Campisi, Roberta Bruschetta, Maria Valeria Maiorana, Gaspare Cusimano, Giovanni Pioggia, Gennaro Tartarisco   +7 more
wiley   +1 more source