Results 201 to 210 of about 139,872 (278)

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, EarlyView.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source

Dosing Reactions and Missed Doses Affect Peanut Oral Immunotherapy Outcomes. [PDF]

J Allergy Clin Immunol Pract
Olayiwola O, Mudd L, Dunaway L, Laidlaw TM, Jones SM, Fulkerson PC, Sanda S, Huffaker MF.   +7 more
europepmc   +1 more source

Dupilumab Dampens Mucosal Type 2 Response During Acetylsalicylic Acid Challenge in N‐ERD Patients

Clinical &Experimental Allergy, EarlyView.
Dupilumab therapy reduced elevated type 2 cytokine responses post‐ASA provocation in N‐ERD patients, independent of ASA tolerance, and revealed novel mechanistic insights by modulating acute type 2 immunity. Transcriptomic analysis showed concurrent downregulation of lipid and peroxisome pathways during ASA challenge in N‐ERD patients after 24 weeks of
Julia Eckl‐Dorna, Christina Morgenstern, Katharina Poglitsch, Tamara Arnoldner, Katharina Gangl, Tina J. Bartosik, Nicholas J. Campion, Aldine Tu, Victoria Stanek, Sven Schneider, Christine Bangert   +10 more
wiley   +1 more source

The construction and refined extraction techniques of knowledge graph based on large language models. [PDF]

Sci Rep
Peng L, Yang P, Juexiang Y, Yuangan L.
europepmc   +1 more source

AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes

Clinical &Experimental Allergy, EarlyView.
ABSTRACT The AllergoOncology field brings together the study of allergic and cancer immune responses, having evolved from early epidemiological studies that reported inverse associations between allergies, IgE and cancer risk. Insights from studying allergic inflammation are revealing previously unappreciated immune mechanisms that confer protective ...
Jakub Zydron, Anishaa Balaji, Jitesh Chauhan, Jack Alder, Xinyi Chen, Anna M. F. Wiegman, Aurelie Poli, Joanna Jacków‐Malinowska, Jack Cheeseman, Daniel I. R. Spencer, James McDonnell, James Spicer, Alexandra J. McCraw, Sophia N. Karagiannis   +13 more
wiley   +1 more source

Clinical and Etiopathological Perspective of Vitamin B1 Hypersensitivity and an Example of a Desensitization Protocol. [PDF]

Life (Basel)
Lis K.
europepmc   +1 more source

Prevention of Subsequent L-Asparaginase Hypersensitivity in Children Through Premedication: A Single-Center Experience. [PDF]

J Pediatr Pharmacol Ther
Saligupta P, Choed-Amphai C, Sathitsamitphong L, Lao-Araya M.   +3 more
europepmc   +1 more source

A Pilot Randomised Controlled Dose‐Ranging Trial of Ant Venom Immunotherapy With and Without Delta‐Inulin Adjuvant

Clinical &Experimental Allergy, EarlyView.
Low dose (25mcg) jack jumper ant venom immunotherapy with or without Advax adjuvant, had similar efficacy to the current standard of care. Reduction in basophil activation test reactivity in response to treatment correlated with sting challenge outcome.
Thanh‐Thao Adriana Le, Troy Wanandy, Griffith B. Perkins, Susan Lester, Wun Yee Lau, Malcolm Turner, Richard J. Woodman, Emily M. Mulcahy, Sherin Vareeckal Joseph, Shweta Mhatre, Simon G. A. Brown, Michael D. Wiese, Nikolai Petrovsky, Robert J. Heddle, Pravin Hissaria   +14 more
wiley   +1 more source

Successful desensitization to liposomal amphotericin B for the treatment of disseminated cryptococcosis in pregnancy: a case report. [PDF]

ASM Case Rep
Ajao SO, Nelson JM, Yassin A, Rosenfeld EB, Brandt JS, Monteleone C, Bhatt PJ, Abdul Azim A.   +7 more
europepmc   +1 more source