Results 161 to 170 of about 69,529 (271)

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, EarlyView.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source

Allopurinol and Febuxostat Hypersensitivity in a Patient with Young Onset Gout: A Case Report. [PDF]

Acta Med Philipp
Yano MAO, Magbitang-Santiago AT.
europepmc   +1 more source

The amino terminal domain of the human α7 nicotinic acetylcholine receptor subunit leads to the functional expression of human/insect receptors

British Journal of Pharmacology, EarlyView.
Human α7 receptors have been characterised in terms of pharmacological properties. Insertion of the N‐terminal domain of the human α7 subunit leads to honeybee and cockroach chimeric receptors activated by ACh and inhibited by α‐Bgt. Insertion of the human cys‐loop leads to cockroach chimeric receptors modulated by PNU.
Alison Cartereau, Chloé Veront, Alexandra Cremades, Priscilla Martin, Remi Gojard, Nicolas Galland, Emiliane Taillebois, Dieudonnée Togbé, Jean‐Yves Le Questel, Steeve H. Thany   +9 more
wiley   +1 more source

Editorial Comment on "Risk Assessment of Cytomegalovirus Reactivation After Kidney Transplantation Under a Universal Preemptive Strategy in the Era of Intravenous Immunoglobulin-Based Desensitization Therapy". [PDF]

Int J Urol
Yamanoi T, Araki M.
europepmc   +1 more source

AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes

Clinical &Experimental Allergy, EarlyView.
ABSTRACT The AllergoOncology field brings together the study of allergic and cancer immune responses, having evolved from early epidemiological studies that reported inverse associations between allergies, IgE and cancer risk. Insights from studying allergic inflammation are revealing previously unappreciated immune mechanisms that confer protective ...
Jakub Zydron, Anishaa Balaji, Jitesh Chauhan, Jack Alder, Xinyi Chen, Anna M. F. Wiegman, Aurelie Poli, Joanna Jacków‐Malinowska, Jack Cheeseman, Daniel I. R. Spencer, James McDonnell, James Spicer, Alexandra J. McCraw, Sophia N. Karagiannis   +13 more
wiley   +1 more source

Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort study. [PDF]

Front Allergy
Torres Górriz MC, Borrás Cuartero J, Viedma Ayllón P, Sánchez Hernández A, Vergara Hernández C, Gil Viciano I, Enrique E.   +6 more
europepmc   +1 more source

Successful rapid desensitization to multiple insulin preparations in an adult with type 1 diabetes: a case report and literature review. [PDF]

Front Endocrinol (Lausanne)
Chen Y, Zhu W, Chen G, Yao J.
europepmc   +1 more source

A Pilot Randomised Controlled Dose‐Ranging Trial of Ant Venom Immunotherapy With and Without Delta‐Inulin Adjuvant

Clinical &Experimental Allergy, EarlyView.
Low dose (25mcg) jack jumper ant venom immunotherapy with or without Advax adjuvant, had similar efficacy to the current standard of care. Reduction in basophil activation test reactivity in response to treatment correlated with sting challenge outcome.
Thanh‐Thao Adriana Le, Troy Wanandy, Griffith B. Perkins, Susan Lester, Wun Yee Lau, Malcolm Turner, Richard J. Woodman, Emily M. Mulcahy, Sherin Vareeckal Joseph, Shweta Mhatre, Simon G. A. Brown, Michael D. Wiese, Nikolai Petrovsky, Robert J. Heddle, Pravin Hissaria   +14 more
wiley   +1 more source

Plasma exchange combined with anti-B-cell therapy enables comparable outcomes between DSA-positive and DSA-negative aplastic anemia after haplo-HSCT: a propensity-score-matched cohort study. [PDF]

Ann Hematol
Tan Z, Hu J, Zhao Y, Hu H, Yu Q, Zhang Y, Wu L, Hu T, Wu D, Ye B, Liu W.   +10 more
europepmc   +1 more source

Diverging in Vivo Immune Response Patterns After Oral Food Challenge in Peanut Allergic Adults

Clinical &Experimental Allergy, EarlyView.
After the oral food challenge, peanut (PN)‐allergic adults were monitored over 4 weeks, which revealed diverging immune response patterns, with strong responders (SR) exhibiting heightened Ara h 2+ B cell expansion, PN sIgE induction and increasing PN‐specific Tconv. Weak responders (WR) had more activated PN‐specific Tregs.
Florent Fauchère, Aikaterina Alexiou, Veronika Höfer, Kirsten Beyer, Sabine Dölle‐Bierke, Andreas Thiel, Margitta Worm, Julian Braun   +7 more
wiley   +1 more source