Results 221 to 230 of about 2,107,565 (334)

Effective Adolescent Hand CRPS Type 1 Treatment Using Ketamine, Gabapentin, and Supraclavicular Nerve Block Catheter-A Case Report. [PDF]

Children (Basel)
Medikondu H, Davit A, Visoiu M.
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Considerations for biologics as front-line treatment in allergic diseases. [PDF]

Front Immunol
Kothari A, Hung L, Upton JEM.
europepmc   +1 more source

Control of Kir channel gating by cytoplasmic domain interface interactions [PDF]

, 2017
Alekseev, Alekseev, Amorós, Antcliff, Bichet, Bushman, Bushman, Clarke, Colin G. Nichols, Drain, Dürr, Enkvetchakul, Enkvetchakul, Enkvetchakul, Eswar, Gloyn, Gribble, Hansen, Hibino, Hilgemann, Huang, Inagaki, Inagaki, Jiang, Koster, Koster, Kumar, Kuo, Kurata, Lederer, Lee, Lee, Lin, Lin, Lin, Linder, Loechner, Lopatin, Lopes, Loussouarn, Loussouarn, Lu, Martin, Nichols, Nichols, Nichols, Nichols, Proks, Proks, Qin, Qin, Qin, Qin, Remedi, Ribalet, Ribalet, Schwalbe, Shimomura, Shizhen Wang, Shyng, Shyng, Shyng, Shyng, Shyng, Shyng, Sievers, Sobolevsky, Sobolevsky, Suh, Sunjoo Lee, Tao, Trapp, Trapp, Whorton, William F. Borschel, Zhang, Zhu, Zubcevic   +77 more
core   +2 more sources

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Long Term Outcomes of Lung Transplantation in Sensitized Patients Following Eculizumab Use With the Desensitization Protocol. [PDF]

Transpl Int
Miyashita Y, Kaiho T, Pinelli DF, Joudi A, John M, Chang A, Thomae BL, Kamar A, Atkinson C, Bharat A, Budinger GRS, Arunachalam A, Kurihara C.   +12 more
europepmc   +1 more source

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Structural insights into kainate receptor desensitization. [PDF]

Nat Commun
Zhou C, Segura-Covarrubias G, Tajima N.
europepmc   +1 more source

Proteolytic degradation of regulator of G protein signaling 2 facilitates temporal regulation of Gq/11 signaling and vascular contraction [PDF]

, 2017
Blumer, Kendall J., Edwards, Alethia J., Kanai, Stanley M., Osei-Owusu, Patrick, Rurik, Joel G.   +4 more
core   +2 more sources

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source