Results 71 to 80 of about 242,610 (251)
, 2019 Par Louis Manière, ingénieur d'étude, responsable de la création du SIG du projet Desert Networks (CNRS, HiSoMA, Lyon) L'un des objectifs du projet ERC Desert Networks est la compréhension et la reconstitution des itinéraires antiques qui ont permis ...
Desert Networks
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The Hybrid Palo Verde 'Desert Museum': A New, Superior Tree for Desert Landscapes
, 1987 A recently released complex hybrid palo verde is described which exhibits the best phenotypic traits of the three species in its parentage. 'Desert Museum' has inherited from Parkinsonia aculeata very rapid growth (up to 2.7 meters, nine feet, per year),
Dimmitt, Mark A.
core +5 more sources
Visual recovery of desert pavement surfaces following impacts from vehicle and foot traffic in the Ross Sea region of Antarctica [PDF]
, 2013 Sites of past human activity were investigated to assess the visual recovery of the desert pavement following impacts from human trampling and vehicle traffic.
O'Neill, Tanya Ann +2 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Editorial: Fire regimes in desert ecosystems: Drivers, impacts and changes
Frontiers in Ecology and Evolution, 2022 Eddie J. B. van Etten +3 more
doaj +1 more source
, 2009 Made available by the Northern Territory Library via the Publications (Legal Deposit) Act 2004 (NT).Family empowerment towards sustainable desert settlements: the Family Wellbeing Program in Alice Springs -- FWB in Alice Springs -- Discussion ...
Desert Knowledge Cooperative Research Centre (Australia) +1 more
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source