Results 71 to 80 of about 31,667 (310)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Spatial patterns of ephemeral plants in Gurbantunggut Desert
, 2007 In the present research, the authors measured parameters of richness, cover and importance value of ephemeral and ephemeroid plants on south-north and east-west transects in the Gurbantunggut Desert in early spring, and investigated and analyzed the ...
Qian YiBing +6 more
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Adaptation: A Way of Life, Plant and Animal Desert Adaptations [PDF]
, 2003 This document provides several activities that show how desert plants and animals are well-adapted to life in the desert and thrive on little moisture and high temperatures. There are extension lessons as well as a drawing activity.
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
ALKALOIDS, SOME CONSTITUENTS AND ANTI-MICROBIAL ACTIVITY OF CONVOLVULUS ARVENSIS L. [PDF]
Egyptian Journal of Desert Research, 2004 Amani S. Awaad +2 more
doaj +1 more source
Minerals content of wild plants from Ashafa, Toroba, Wahat and Wehait (Saudi Arabia)
, 1993 Four desert plant species (Alhagi maurorum, Peganum harmala, Zilla spinosa, Zygophyllum album) from Ashafa, Toroba, Wahat and Wehait (Saudi Arabia) were col1ected and analyzed for heavy metal contents.
Alfarhan, A.H., Hashem, A.R.
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source