Results 11 to 20 of about 22,605 (200)

The Best Iron Chelation Therapy in Major Thalassemia Patients is Combination of Desferrioxamine and Deferiprone [PDF]

International Journal of Hematology-Oncology and Stem Cell Research, 2011
Introduction: The best and effective iron chelation remain one of the major strategy in clinical management of thalassemia major patients. The purpose of this study was to evaluate the safety and effectiveness of combined therapy with Desferrioxamine and
Mohammad Ali Mashhadi, Ali Reza Rezvani, Mohammad Naderi, Ebrahim miri moghaddam   +3 more
doaj   +2 more sources

Combined therapy with deferiprone and desferrioxamine in thalassemia major [PDF]

Haematologica, 2005
BACKGROUND AND OBJECTIVES: Effective and convenient iron chelation remains one of the main targets of clinical management of thalassemia major. The combined treatment with desferrioxamine and deferiprone could have an increased chelation efficacy and ...
R Origa, P Bina, A Agus, G Crobu, E Defraia, C Dessi, G Leoni, PP Muroni, R Galanello   +8 more
doaj   +3 more sources

Identification of Siderophores With Unexpected Antibacterial Properties From Actinoplanes teichomyceticus. [PDF]

Chembiochem
Here, we report isolation of acyl‐desferrioxamines from Actinoplanes teichomyceticus as a mixture of iron and aluminum complexes. The fraction containing these molecules exhibited antibacterial activity. We synthesized these molecules and found that they only exhibited antibacterial activity in the presence of aluminum.
Oyedele AS, Jana S, Jeon K, Vazrala N, Stec DF, Kim K, Sulikowski GA, Walker AS.   +7 more
europepmc   +2 more sources

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases. [PDF]

FEBS Lett
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Halliwell B.
europepmc   +2 more sources

Remodelling of Skeletal Muscle During Iron Deficiency Anaemia and Recovery After Intravenous Iron Therapy. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Background The global prevalence of iron deficiency anaemia (IDA) is about 25% and even higher in women of reproductive age and children. IDA can impair skeletal muscle by disrupting oxygen utilization, energy production and contractile function. Haematological effects of intravenous (IV) iron therapy in IDA are well studied, but its impact on
Pertler E, Wagner SA, Panzer M, Obholzer L, Sonnenburger Y, Troppmair MR, Saretto M, Schaefer B, Manzl C, Oberacher H, Sarg B, Faserl K, Redl S, Hess MW, Telser T, Popottnigg JP, Gronich-Wondrak P, Tilg H, Zoller H.   +18 more
europepmc   +2 more sources

Homo-/Heterodimeric Substrates Bias the Type and Multiplicity of Hydroxamic Acid Chelators Assembled by a NIS Synthetase DesD. [PDF]

Chemistry
Chemoenzymatic reactions using the siderophore synthetase DesD from Salinispora tropica and hydroxamic acid substrates (native, non‐native) with different multiplicities (monomer, dimer) and components (homo‐/heterodimer) followed different reaction trajectories, which biased the architectures of the chelator major products and indicated DesD contains ...
Rosser CA, Markham TE, Codd R.
europepmc   +2 more sources

Contemporary Management of Thalassemia: A Perspective on Current Standards and the Emergence of FDA-Approved Oral Therapy. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Thalassemia is an inherited hemoglobin disorder characterized by ineffective erythropoiesis, chronic anemia, and progressive multisystem complications that require lifelong management. Current treatment relies on regular red blood cell transfusions, iron chelation therapy, and supportive multidisciplinary care, while ...
Zainab F, Hasan AH, Abid MH, Abid MA.
europepmc   +2 more sources

Ocular Complications in Patients With Transfusion-Dependent Beta-Thalassemia Receiving Deferasirox: A Cross-Sectional Study. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Transfusion‐dependent beta‐thalassemia is a chronic hematologic disorder necessitating lifelong blood transfusions and iron chelation therapy, which can lead to systemic and ocular complications. This study aimed to assess the frequency and characteristics of ocular complications in beta‐thalassemia patients treated with ...
Medghalchi A, Kanafi AR, Alizadeh Y, Baghersalimi A, Doorandish M, Hassanzadeh Rad A, Kianmehr S, Darbandi B.   +7 more
europepmc   +2 more sources

Calibration and count rate performance of NaI(Tl) gamma counters for quantifying the activity ⁸⁹Zr radiopharmaceuticals. [PDF]

J Appl Clin Med Phys
Abstract Background Quantification of low activity samples using gamma counters is a common technique when investigating the biodistribution of experimental radiopharmaceuticals. Several human and pre‐clinical trials have investigated 89Zr labeled compounds, utilizing gamma counter to quantify activity in blood or animal samples.
Silosky M.
europepmc   +2 more sources

Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease. [PDF]

, 2010
Oxidative stress is common in inflammatory processes associated with many diseases including Chagas' disease. The aim of the present study was to evaluate, in a murine model, biomarkers of oxidative stress together with components of the antioxidant ...
Olindo Assis Martins-Filho, Martins-Filho, Olindo Assis, Cláudia Martins Carneiro, Washington Luiz Tafuri, Santos, Silvana Maria Elói, Andréa Teixeira-Carvalho, Vieira, Paula Melo de Abreu, Carneiro, Cl??udia Martins, de Abreu Vieira, Paula Melo, Francisco, Amanda Fortes, Paula Melo de Abreu Vieira, Silvana Maria Elói-Santos, Silva, Maisa, Ara??jo, M??rcio Sobreira Silva, Tafuri, Washington Luiz, Araújo, Márcio Sobreira Silva, Carvalho, Andréa Teixeira de, Carvalho, Andr??a Teixeira, Pedrosa, Maria L??cia, Amanda Fortes Francisco, Arantes, Jerusa Marilda, Elói-Santos, Silvana Maria, Maisa Silva, Teixeira-Carvalho, Andréa, Jerusa Marilda Arantes, Márcio Sobreira Silva Araújo, Carneiro, Cláudia Martins, Martins Filho, Olindo Assis, Santos, Silvana Maria El??i, Pedrosa, Maria Lúcia, Maria Lúcia Pedrosa   +30 more
core   +1 more source