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The science behind banning desflurane

European Journal of Anaesthesiology, 2022
Potent inhaled anaesthetics are halogenated hydrocarbons with a large global warming effect. The use of fluorinated hydrocarbons (most are not anaesthetics) are being restricted but volatile anaesthetics have been exempted from legislation, until now ...
J. Hendrickx   +3 more
semanticscholar   +1 more source

Activation of Orexinergic Neurons Inhibits the Anesthetic Effect of Desflurane on Consciousness State via Paraventricular Thalamic Nucleus in Rats

Anesthesia and Analgesia, 2021
BACKGROUND: Orexin, a neuropeptide derived from the perifornical area of the hypothalamus (PeFLH), promotes the recovery of propofol, isoflurane, and sevoflurane anesthesias, without influencing the induction time. However, whether the orexinergic system
Shiyi Zhao   +14 more
semanticscholar   +1 more source

The impact of bolus versus continuous infusion of intravenous ketamine on bispectral index variations and desflurane administration during major surgery

European Journal of Anaesthesiology, 2021
Supplemental Digital Content is available in the text BACKGROUND Although ketamine, a NMDA-receptor antagonist, tends to increase the bispectral index (BIS), it remains a widely used analgesic whenever administered in low doses during major surgery ...
Lucie Carrara   +10 more
semanticscholar   +1 more source

Desflurane Should Des-appear: Global and Financial Rationale.

Anesthesia and Analgesia, 2020
Desflurane is a volatile anesthetic agent used throughout the world. Since 2001, global emissions of desflurane have increased from 150 tons per year to 960 tons per year in 20141 and this trend is expected to continue.
Matthew J. Meyer
semanticscholar   +1 more source

A comparison of postoperative respiratory complications associated with the use of desflurane and sevoflurane: a single‐centre cohort study

Anaesthesia, 2020
Sevoflurane and desflurane are the most commonly used volatile anaesthetics for maintenance of anaesthesia. In this study, we aimed to evaluate the relationship between choice of volatile anaesthetic and early postoperative respiratory complications, and
L. Zucco   +6 more
semanticscholar   +1 more source

Exposure to desflurane anesthesia confers colorectal cancer cells metastatic capacity through deregulation of miR-34a/LOXL3.

European Journal of Cancer Prevention, 2020
Due to high potency and low toxicity, desflurane has been widely used during surgery. Recent evidence that the use of desflurane was associated with colorectal cancer (CRC) tumor metastasis and poor prognosis raising concerns about the safety of ...
Junyi Ren   +3 more
semanticscholar   +1 more source

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