Results 81 to 90 of about 4,589,695 (260)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Developing residents' feedback literacy in emergency medicine: Lessons from design-based research. [PDF]

AEM Educ Train, 2023
Noble C, Young J, Brazil V, Krogh K, Molloy E.   +4 more
europepmc   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice

Nature Communications
The accumulation of senescent cells in white adipose tissue (WAT) is closely associated with the functional decline of WAT and plays a causal role in the pathogenesis of metabolic diseases.
Eok-Cheon Kim, Han-Byul Jung, Yu-kyoung Park, Youlim Son, Hye-Na Cha, Yash Patel, Ju Hee Lee, Minah Choi, Soyoung Park, Il-Kug Kim, Lauren Pickel, Seungju Lee, Yuna Ha, Min-Gyeong Shin, Qiwei Zhang, Jielin Yang, Bruno Rodrigues de Oliveira, Nathaniel Vo, Annie Yew, Jacques Togo, Kafi N. Ealey, Su-Ryun Jung, Sunjin Moon, Hye-Jin Yoon, Jee-Young Lee, Hoon-Ki Sung, Jae-Ryong Kim, So-Young Park   +27 more
doaj   +1 more source

The Application of a Design-Based Research Framework for Simulation-Based Education. [PDF]

Cureus, 2022
Momand B, Hamidi M, Sacuevo O, Dubrowski A.   +3 more
europepmc   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Design of a micro-learning framework and mobile application using design-based research. [PDF]

PeerJ Comput Sci, 2023
Robles H, Jimeno M, Villalba K, Mardini I, Viloria-Nuñez C, Florian W.   +5 more
europepmc   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Using Design-Based Research for a Technological Intervention to Promote Parental Involvement in Kindergarten. [PDF]

SN Comput Sci, 2023
Laranjeiro D, Antunes MJ, Santos P.
europepmc   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source