Results 121 to 130 of about 25,875,084 (346)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Proceedings of the International Conference of Contemporary Affairs in Architecture and Urbanism-ICCAUAThe unpredictable increase in the number of motor vehicles and the population due to changes in the urban structure has revealed the need for new public areas, recreation and social contact points for pedestrians, especially in city centers.
Elif KORKMAZ
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
RELIABILITY OF MACHINE ELEMENTS IN WIND TURBINES [PDF]
Fiabilitate şi Durabilitate, 2010 Worldwide electrical energy production generated by wind turbines grows at a rate of 30 percent. This doubles the total production every three years. At the same time the power of individual stations goes up by 20 percent annually.
Willi GRUENDER
doaj
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Design Annual (2017-2018) [PDF]
, 2018 Design Annual is the yearly compilation of the activities and works by students and faculty at University of Central Oklahoma's Department of Design. UCO Library's Digital Initiatives Working Group has provided 2 copies of each issue: one file is the ...
University of Central Oklahoma. Department of Design.
core
Tasarımda Arte Povera Ethosu ve Örnekleri Üzerine Bir Değerlendirme
PLANARCH - Design and Planning ResearchBirçok ülkede siyasal ve toplumsal hareketler farklı dönemlerde olumsuz durumların yaşanmasına sebep olmuş, tüm bu sıkıntılı süreçler yaşamın her alanında farklı etkiler/değişimler/oluşumlar ortaya çıkarmıştır.
Merve Buldaç
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source