Results 121 to 130 of about 15,545,883 (264)
, 2020 Collaborative arrangements between users and designers today are enacted in a broadening array of circumstances. These include extended, even years-long projects within corporations, the public and third sectors, as well as open-ended, peer-to-peer open ...
Hyysalo, Sampsa +3 more
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Moscow Agglomeration: the 1st Stage of the Competition
Проект Байкал, 2012 - Strelka Institute for Media, Architecture and Design
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Design Annual (2016-2017) [PDF]
, 2017 Design Annual is the yearly compilation of the activities and works by students and faculty at University of Central Oklahoma's Department of Design. UCO Library's Digital Initiatives Working Group has provided 2 copies of each issue: one file is the ...
University of Central Oklahoma. Department of Design.
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Mindfulness and resource-sensitive design : a literature overview and an agenda for research
21st International Conference on Engineering Design (ICED 17), Vancouver, Canada, 21-25 August 2017202403 bckwVersion of RecordSelf-fundedPublishedVoR ...
de Bont, C, Chan, WMH
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Design Annual (2015-2016) [PDF]
, 2016 Design Annual is the yearly compilation of the activities and works by students and faculty at University of Central Oklahoma's Department of Design. UCO Library's Digital Initiatives Working Group has provided 2 copies of each issue: one file is the ...
University of Central Oklahoma. Department of Design.
core
A safe design strategy fosters innovative solutions for managing workplace risk in industrial design
Maǧallaẗ Al-Turāṯ wa Al-TaṣmīmThe industrial designer plays an essential role in influencing aspects of safety, health, and risk management in workplace, in addition to achieving the safe design of products and structures that he develops before building and implementing them in ...
Associate Professor. Mohamed Mohamed Ryead
doaj +1 more source