Design Space Constraints and the Cultural Taxonomy of European Final Palaeolithic Large Tanged Points: A Comparison of Typological, Landmark-Based and Whole-Outline Geometric Morphometric Approaches [PDF]
, 2021 David N. Matzig +2 more
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Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
And, 2020 Throughout the history of design, we have been able to understand how often production and design methods have undergone radical and substantial changes that project us into a future that is increasingly technological and within everyone's reach.
Alessandro Spennato, Simone Toscano
doaj
Simulations of the grand design galaxy M51: a case study for analysing tidally induced spiral structure [PDF]
, 2010 Clare L. Dobbs +3 more
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Rational design of hydrogels for immunomodulation [PDF]
, 2022 Wenhuan Bu +4 more
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EXPLORATION METHOD OF ROSTER DESIGN DEVELOPMENT WITH METAL WASTE IN TUMANG VILLAGE CEPAGA BOYOLALI [PDF]
, 2019 In Tumang village as a center for copper handicrafts, the problem that arises is the abundant metal waste but has not been used optimally. The aim is to develop a roster design made from metal waste with consideration of aesthetic appearance and ...
Setyawan, S. (Setyawan) +2 more
core
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Recent Advances in Photocatalytic Removal of Microplastics: Mechanisms, Kinetic Degradation, and Reactor Design [PDF]
, 2022 Wael Hamd +3 more
openalex +1 more source
Design of Stocking Density of Broilers for Closed House in Wet Tropical Climates [PDF]
, 2014 The objectives of this research were to: 1) design the stocking density of broiler reared at a closed house system in wet tropical climates based on the heat released by broiler, 2) design broiler harvesting system based on the housing heat load, and 3 ...
Erizal, E. (Erizal) +3 more
core
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source