Results 171 to 180 of about 4,753,099 (348)

Key Concepts in Ligand Design [PDF]

, 2016
Rylan J. Lundgren, Mark Stradiotto
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

The ClaudicatioNet concept: design of a national integrated care network providing active and healthy aging for patients with intermittent claudication

Vascular Health and Risk Management, 2012
Gert-Jan Lauret,1,2 Harm JH Gijsbers,3 Erik JM Hendriks,2 Marie-Louise Bartelink,4 Rob A de Bie,2 Joep AW Teijink1,2 On behalf of the ClaudicatioNet Study Group members1Department of Vascular Surgery, Catharina Hospital, Eindhoven, The Netherlands ...
Lauret GJ, Gijsbers HJ, Hendriks EJ, Bartelink ML, de Bie RA, Teijink JA   +5 more
doaj  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Intelligent Face Recognition System Based on Universal Design Concept.

Comput Intell Neurosci, 2022
Li Z, Shin K.
europepmc   +1 more source

Water Supply and Drainage Design for Prefabricated Buildings Under the Green Building Concept

, 2023
Jingjing Sun
openalex   +2 more sources

A design concept for an MMIC microstrip phased array [PDF]

A conceptual design for a microstrip phased array with monolithic microwave integrated circuit (MMIC) amplitude and phase controls is described. The MMIC devices used are 20 GHz variable power amplifiers and variable phase shifters recently developed by ...
Acosta, R., Lee, R. Q., Smetana, J.
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Application of the Safe-By-Design Concept in Crop Breeding Innovation. [PDF]

Int J Environ Res Public Health, 2020
van der Berg JP, Kleter GA, Battaglia E, Bouwman LMS, Kok EJ.   +4 more
europepmc   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source