Results 81 to 90 of about 4,347,183 (334)
Purification tags markedly affect self‐aggregation of CPEB3
FEBS Letters, EarlyView.Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito +6 more
wiley +1 more source
NTF model concept for the X-29A. Part 2: Design and fabrication concept [PDF]
, 1983 The first concept was done to determine if a small model to fit the NASA Langley sizing criteria could accommodate aerodynamic and mechanical requirements.
Toscano, G.
core +1 more source
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
A concept design for an ultra-long-range survey class AUV [PDF]
, 2007 Gliders and flight-style Autonomous Underwater Vehicles (AUVs) are used to perform perform autonomous surveys of large areas of open ocean. Glider missions are characterized by their profiling flight pattern, slow speed, long range (1000s of km) and many
Furlong, Maaten E. +2 more
core +2 more sources
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Concept models for design practice
Bitácora Urbano Territorial, 2017 Concept models are common guides to living, and some more specialized ones, which have been developed and validated in other fields have been adopted by designers for use in their work. In particular, concept models serve as templates for decision-making
Stan Ruecker
doaj +1 more source
Design Concept for a Failover Mechanism in Distributed SDN Controllers [PDF]
, 2017 Software defined networking allows the separation of the control plane and data plane in networking. It provides scalability, programmability, and centralized control. It will use these traits to reach ubiquitous connectivity.
Kong, Nathan
core +2 more sources
PickCells: A Physically Reconfigurable Cell-composed Touchscreen [PDF]
, 2019 Touchscreens are the predominant medium for interactions with digital services; however, their current fixed form factor narrows the scope for rich physical interactions by limiting interaction possibilities to a single, planar surface.
Coutrix, C. +12 more
core +5 more sources
Molecular Oncology, Volume 19, Issue 7, Page 1918-1934, July 2025.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source