Results 41 to 50 of about 1,483,458 (304)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
De novo design of bioactive protein switches. [PDF]
, 2019 Allosteric regulation of protein function is widespread in biology, but is challenging for de novo protein design as it requires the explicit design of multiple states with comparable free energies. Here we explore the possibility of designing switchable
Baker, David +14 more
core
Optimization of graded multilayer designs for astronomical x-ray telescopes [PDF]
, 1999 We developed a systematic method for optimizing the design of depth-graded multilayers for astronomical hard-x-ray and soft-γ-ray telescopes based on the instrument’s bandpass and the field of view.
Christensen, Finn E. +3 more
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Design e Tecnologia, 2016 Este estudo foi construído a partir da percepção de que a evolução das tecnologias e, sobretudo, o aprimoramento da comunicação em dispositivos móveis, impacta diretamente no processo de desenvolvimento de aplicativos (apps) e softwares e na relação do ...
Ana Claudia Dalagnoli +1 more
doaj +3 more sources
Music Learning Tools for Android Devices [PDF]
, 2016 In this paper, a musical learning application for mobile devices is presented. The main objective is to design and develop an application capable of offering exercises to practice and improve a selection of music skills, to users interested in music ...
Barbancho-Perez, Ana Maria +3 more
core
Intersubband carrier scattering in n- and p-Si/SiGe quantum wells with diffuse interfaces [PDF]
, 2008 Scattering rate calculations in two-dimensional Si/Si1−xGex systems have typically been restricted to rectangular Ge profiles at interfaces between layers.
A. Valavanis +5 more
core +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Emerging from the MIST: A Connector Tool for Supporting Programming by Non-programmers [PDF]
, 2010 Software development is an iterative process. As user re-quirements emerge software applications must be extended to support the new requirements. Typically, a programmer will add new code to an existing code base of an application to provide a new ...
Bhatia, Saurabh +3 more
core +1 more source