Results 101 to 110 of about 11,078,300 (297)

Editorial: Design Pedagogy

, 2020
The number of DRS 2020 paper submissions relating to design education reflects the ongoing and active engagement of the design education research community. 2020 will, of course, be remembered for the Covid-19 pandemic and its impact on design education programs and colleagues around the world.
Jones, Derek, Nielsen, Liv Merete, Digranes, Ingvild, Lotz, Nicole, Noel, Lesley-Ann, Börekcle, Naz A. G. Z.   +5 more
openaire   +1 more source

Cardume - o fazer cerâmico como linguagem para o design editorial [PDF]

Trabalho de Conclusão de Curso (Graduação)O presente trabalho propõe a criação de um projeto de design editorial para um catálogo expográfico impresso, a partir da aplicação da identidade visual da marca de cerâmicas artesanais Tocaia, criada pelo autor.
Lopes, André Cunha Garcia
core   +1 more source

Recent Developments in Machine Design, Automation and Robotics

Machines
This editorial introduces a Special Issue of Machines entitled “Recent Developments in Machine Design, Automation and Robotics” [...]
Raul D. S. G. Campilho
doaj   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7

Advanced Science, EarlyView.
Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Yunkyung Kim, Gaeun Lee, Saemin An, Hanseul Park, Hongwon Kim, Jisung Kim, Soi Kang, Sumin Kim, Daeyeol Kwon, Jeonghyun Park, Yerim Hwang, Seonghun Kim, Xiuwen Yuan, Jaehoon Jeong, Hamin Lee, Hui Kwon Kim, Jongpil Kim   +16 more
wiley   +1 more source

Revista Autismo: identidade inclusiva no design gráfico

Diálogo com a Economia Criativa
Este artigo apresenta uma pesquisa qualitativa de análise de conteúdo das 27 edições do periódico trimestral Autismo, o primeiro da América Latina a abordar o tema.
Maria Fernanda Guimarães
doaj   +2 more sources

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Continuous Evolution System Based on Toxin–Antitoxin System Combined with Base Deaminase Accelerates the In Vivo Modification of Target Proteins

Advanced Science, EarlyView.
The promoted Escherichia coli‐assisted continuous evolution (PEACE) system operates through a stringent three step genetic circuit: target gene mutation via a deaminase–T7 RNA polymerase (T7 RNAP) fusion, coupling variant function to antitoxin expression, and growth based selection of surviving cells.
Xinyu Zhang, Zhanzhi Liu, Ying Xu, Mingjing Sun, Guangzhen Zhou, Deming Rao, Xiaoqian Chen, Sheng Wang, Zhigang Li, Yan Huang, Jing Wu   +10 more
wiley   +1 more source

O projeto gráfico de periódicos científicos: uma contribuição aos roteiros de avaliação

Em Questão, 2005
O presente artigo estuda a relação entre projetos gráfico e editorial de periódicos na comunicação científica. Para isso, apresenta e discute os modos como estes veículos vêm sendo avaliados, bem como as peculiaridades do processo de design editorial e ...
Raquel da Silva Castedo, Ana Cláudia Gruszynski   +1 more
doaj  

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source