Results 121 to 130 of about 1,258,449 (312)
Optimal boundary geometry in an elasticity problem: a systematic adjoint approach [PDF]
, 2009 p. 509-524In different problems of Elasticity the definition of the optimal geometry of the boundary, according to a given objective function, is an issue of great interest.
CASTRO, C. +2 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao +12 more
wiley +1 more source
Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions
Advanced Science, EarlyView.This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang +4 more
wiley +1 more source
Internet y la mosca del vinagre [PDF]
, 2013 The daily expansion of the Internet, both in volume and an importance, calls for an analisys of the situation in order to find valid rules or parameters.
Larrea, Quim
core
ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology
Advanced Science, EarlyView.This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li +25 more
wiley +1 more source
Smart energy systems and 4th generation district heating
International Journal of Sustainable Energy Planning and Management, 2016 Energy systems are becoming increasing increasingly complex, integrating across traditionally separate sectors such as transportation, heating, cooling and electricity.
Poul Alberg Østergaard +2 more
doaj +1 more source
Timber roof structure for outdoor auditorium in Parque Paraiso, San Blas (Madrid)
, 2009 p. 468-475A timber shell structure is designed to provide covering for an outdoor auditorium in Madrid (Spain). The covering comprises five independent overlapped marquees with similar shape but diverse dimensions.
ANTON, Arturo +2 more
core
Digital Tectonics as a Morphogenetic Process
, 2010 p. 938-948Tectonics is a seminal concept that defines the nature of the relationship between architecture and its structural properties. The changing definition of the symbiotic relationship between structural engineering and architectural design may ...
OXMAN, Rivka
core
Programmable RNA N6,2´‐O‐Dimethyladenosine Editing
Advanced Science, EarlyView.ABSTRACT N6,2’‐O‐dimethyladenosine (m6Am) is a prevalent RNA modification located at the first transcribed nucleotide adjacent to the 5′ cap of mRNAs, where it has been implicated in gene regulation. However, the lack of methods for precise, transcript‐specific manipulation of m6Am has limited its functional dissection.
Yang Li +9 more
wiley +1 more source
Advanced Science, EarlyView.Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole +17 more
wiley +1 more source