Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Shaping Entrepreneurial Design Identity in Design Education
She Ji: The Journal of Design, Economics and InnovationThis article employs social identity theory and findings from research on design identity, entrepreneurial identity, and entrepreneurship education to discuss transdisciplinary design education at the intersection of design and entrepreneurship, which ...
Beate Cesinger, Sandra Dittenberger
doaj +1 more source
Virtual fieldwork on a ship's bridge: virtual reality-reconstructed operation scenarios as contextual substitutes for fieldwork in design education. [PDF]
Virtual Real, 2022 Frydenberg SG, Nordby K, Nordby K.
europepmc +1 more source
Architectural Travelers: The Role of Field Trips in Spatial Design Education
, 2021 Berk Kesim, Nilüfer Baturayoğlu Yöney
openalex +2 more sources
Circular 02/15 : centres of vocational excellence : update for further education colleges [PDF]
, 2002 "This circular provides updated guidance to Further Education, Tertiary and Specialist Colleges of Agriculture, Horticulture, Art and Design, Performing Arts, Sixth Form Colleges, Designated Institutions and Higher Education Institutions on the Learning
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
New Strategies and Practices of Design Education Under the Background of Artificial Intelligence Technology: Online Animation Design Studio. [PDF]
Front Psychol, 2022 Tang T, Li P, Tang Q.
europepmc +1 more source
Sustainability in design: now! Challenges and opportunities for design research, education and practice in the XXI century [PDF]
, 2010 Copyright @ 2010 Greenleaf PublicationsLeNS project funded by the Asia Link Programme, EuropeAid, European ...
Ceschin, F, Vezzoli, C, Zhang, J
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source