Results 131 to 140 of about 18,580,692 (312)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Reconfiguring graphic design education for generative AI in higher education: a human-agency and adaptive-curriculum framework

open access: yesFrontiers in Education
IntroductionGenerative AI creates a curriculum-transformation problem by redistributing activities through which disciplinary expertise is learned, practised, demonstrated, and assessed. This study examines that problem within graphic design education as
Khaled Mostafa Ahmed Mohamed
doaj   +1 more source

How future proof is design education? A systematic review. [PDF]

open access: yesInt J Technol Des Educ, 2023
Brosens L   +3 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

The Contradiction of Institutional Diversity in the Design Student Body

open access: yesDiseña
The United States of America has pioneered initiatives, policies, and pedagogies to diversify its higher education student bodies. In design education, for instance, students are taught to self-represent their cultures and those of their ancestors ...
Hien L. D. Phan   +1 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

From Tutor-led to Student-led design education: the Global Studio [PDF]

open access: yes, 2013
“Tutor-led” design education has been argued to be a system where lecturers are at the centre of teaching & learning activities and where educators’ tastes strongly influence students’ outcomes.
Bohemia, E.   +2 more
core  

Editorial: Teaching and learning human–computer interaction (HCI): current and emerging practices

open access: yesFrontiers in Computer Science, 2023
Craig M. MacDonald   +7 more
doaj   +1 more source

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