Results 111 to 120 of about 18,580,692 (312)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

When matter leads to form: Material driven design for sustainability

Temes de Disseny, 2018
This article presents the argument that a conventional, form-focused design process causes a lack of knowledge regarding materials and, as a result, creates a knowledge barrier between the designer and the product – a barrier that acts not only against ...
Mette Bak-Andersen
doaj  

ARTIFICIAL INTELLIGENCE IN THE FORMATION OF CULTURAL COMPETENCE OF FUTURE DESIGNERS: THE DIDACTIC ASPECT OF THE CREATIVE ECONOMY

Economics & Education
The subject of this study is the didactic potential of artificial intelligence in the formation of cultural competence among future designers in the context of the creative economy.
Tetiana Zubko, Marianna Adamovska
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Reflections in design education using Visual technology [PDF]

, 2014
Product design students are trained to express themselves through visual media like two - dimensional ( 2D ) and 3D drawing, prototyping, and digital media. Thus, written language is not always their first choice of communicati on. The aim
Sjøvoll, Vibeke, Stoltenberg, Einar
core  

The position of three-dimensional modeling and visualization techniques in industrial design education

, 2012
The purpose of this research is to determine the position of three-dimensional modeling and digital visualization within the scope of concept and product development process in the undergraduate education in Middle East Technical University Faculty of ...
Sarisin, Merve, Akiner, Dilem, Sarışın, Merve, COŞKUN, MERVE   +3 more
core   +1 more source

Evaluating the Effectiveness of VR in Architectural Design Education: A Comparison Across Student Levels Using Pointing Out Mistakes in Design Plans

Buildings
Background: Virtual reality (VR) has attracted increasing attention in architectural design education because of its potential to support spatial cognition and embodied understanding of architectural space. Compared with conventional two-dimensional (2D)
Ning Hou, Daisaku Nishina, Sayaka Kindaichi, So Sugita, Shunki Nishii   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Material Selection in Industrial Design Education : A literature review

, 2016
This study reviews literature on the aspects of material selection within the field of industrial design education, specifically focusing on existing material selection tools and guidelines used in industrial design education.
Santosh, Jagtap, Jagtap, Santosh, ASBJØRN SÖRENSEN, CHARLOTTE, Warell, Anders   +3 more
core  

Quantifying the Fluency Illusion in AI-Augmented Design Education: A Behavioral Soft-Sensor Framework for Decoding Human–AI Collaboration Patterns

Applied System Innovation
Generative artificial intelligence (GenAI) has transformed design education, yet growing evidence suggests that the fluency of AI-generated outputs may create a “fluency illusion”—a metacognitive bias whereby learners conflate polished AI artifacts with ...
Yanfei Tang, Wai Yie Leong
doaj   +1 more source