Results 91 to 100 of about 18,580,692 (312)

Design Entrepreneurship in Product Design Education

Procedia - Social and Behavioral Sciences, 2012
AbstractDesign entrepreneurship is about producing and marketing the intellectual properties of a viable concept in terms assuming risks, financing and managing. So this study is about a discussion on building entrepreneurship skills in design education.
openaire   +3 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Editorial Track 02: Empowering Critical Design Literacy: Exploring Practices, Discourses and Implications in and Across Design Education from Kindergarten to PhD

, 2021
In track 02, we invited design researchers and educators to explore, and crack open critical design literacy as a subset of design literacy. At the core of critical design literacy, we suggested the ability to connect to real-world dilemmas with empathy,
Maus, Ingvill Gjerdrum, Reitan, Janne Beate, Brænne, Karen, Lutnæs, Eva, Homlong, Siri, Hofverberg, Hanna, Fauske, Laila Belinda   +6 more
core  

Integrating image-generative AI into conceptual design in computer-aided design education: Exploring student perceptions, prompt behaviors, and artifact creativity

Educational Technology & Society
Although image-generative AI (GAI) has sparked heated discussion among engineers and designers, its role in CAD (computer-aided design) education, particularly during the conceptual design phase, remains not sufficiently explored.
Wangda Zhu, Wanli Xing, Eddy Man Kim, Chenglu Li, Yuanzhi Wang, Yoon Yang and Zifeng Liu
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

It takes a village: Community based participatory research as a design research tool

Discern, 2020
Design has transitioned progressively from a consumer-focused discipline to a human-centred one, with a more complex agenda. Design thinking has been successfully deployed as an agent for social change. In this paper we take a trans-disciplinary approach
Dhriti Dhaundiyal, Richa Pant
doaj  

Identifying the Components of Fostering an Entrepreneurial Mindset in Design Education Students [PDF]

هنرهای زیبا. هنرهای تجسمی
The entrepreneurial mindset encompasses a range of qualities that enable individuals to identify opportunities, innovate, and create sustainable ventures.
Mohammad Salimian Rizi, Maryam Khalili, Mehran Fateminia, Farzaneh Eeftekhary   +3 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source