Results 161 to 170 of about 18,580,692 (312)
Development of functional mock-ups for engineering design education
, 2011 Hands-on interaction with machinery is a possibility to enhance engineering design education. Based on the existing approach of an interactive machine part exhibition [1], a concept has been created to improve a first year drawing course by the use of ...
Krause, Dieter, Beckmann, Gregor
core +1 more source
Mixed Assessment of Virtual Serious Games Applied in Architectural and Urban Design Education. [PDF]
Sensors (Basel), 2021 Fonseca D +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Nothing Special? (Activist) Design Skills for the 21st Century
Kepes, 2012 This isn’t just a challenge for designers, but also for policy, design research and the representation of design through its exhibition or publication. Design is embracing new sets of skills that require extended thinking.
Guy . Julier
doaj
Research on Integrated Innovation Design Education for Cultivating the Innovative and Entrepreneurial Ability of Industrial Design Professionals. [PDF]
Front Psychol, 2021 Hu W, Hu Y, Lyu Y, Chen Y.
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Feasibility Analysis of Mutual Benefit Cooperation between Environment-Embedded Art Design Education and Local SMEs Development Based on Improved Grey Analysis. [PDF]
J Environ Public Health, 2022 Miao W, Zhou H.
europepmc +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source