Results 141 to 150 of about 4,260,477 (269)
Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma
BMC MedicineGlioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a universally lethal prognosis despite maximal standard therapies. Here, we present a consensus treatment protocol based on the metabolic requirements of GBM cells for the two ...
Tomás Duraj +48 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Causality in Statistical Power: Isomorphic Properties of Measurement, Research Design, Effect Size, and Sample Size. [PDF]
Scientifica (Cairo), 2016 Heidel RE.
europepmc +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Using design to change management education: radical innovation vs entertaining facelift
, 2017 Design has assumed so far a central role in management, both as a key competence used by designers to boost the process of product innovation (Von Stamm, 2004; Brown, 2009; Martin, 2009; Lockwood, 2010; Verganti, 2003) and as a point of critical re ...
Daniela Pavan, Monica Calcagno
core
Intraclass correlation and design effect in BMI, physical activity and diet: a cross-sectional study of 56 countries. [PDF]
BMJ Open, 2016 Masood M, Reidpath DD.
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Die design effect on internal die drool phenomenon
, 2015 In this work, the effect of die exit design on the internal die drool phenomenon occuring during extrusion of HDPE has been experimentaly investigated. It has been revealed, that firstly, the effect of flared length and die exit angle on the internal die
Zatloukal, Martin, Musil, Jan
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source