Results 121 to 130 of about 4,260,477 (269)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Snow design from Lapland : initiating cooperation

open access: yes, 2014
acceptedVersionei tietoa ...

core  

Social media: Third-person perceptions and insights on architecture [PDF]

open access: yesUrbanism. Arhitectura. Constructii, 2018
Perceptions of architecture vary depending on the reader. This study is based on an experiment involving social media. A provocative architectural photomontage is shared on Facebook without using the sponsored feature.
Lino Bianco
doaj  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Chinese medicine (Tiao-Chang Ke-Min granules) placebo and nocebo effects for diarrhea-predominant irritable bowel syndrome: a study protocol for a randomized controlled trial based on a balanced experimental design

open access: yesBMC Complementary Medicine and Therapies
Background Irritable bowel syndrome (IBS) is a common gut-brain interaction disorder, prevalent in the general population. Current medication treatments often leave patients undertreated.
Qian Li   +4 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

TOLERANCE DESIGN OF THE JOURNAL-BEARING CINEMATIC JOINT. NUMERICAL ANALYSIS OF THE EFFECT OF THE SHAPE VARIATIONS ON THE PERFORMANCES

open access: yes, 2002
In this work the authors deal with the problem regarding tolerance design of the journal – bearing kinematic joint, in which hydrodynamic lubrication conditions are realised.
PATALANO, STANISLAO   +4 more
core  

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

open access: yesFEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez   +2 more
wiley   +1 more source

Empowering children's food packaging design with empathy theory: application scenarios, challenges, and improvements

open access: yesShipin yu jixie
From the perspective of the reinforcement effect that empathy theory has on children's food packaging design, the current application of this theory in this field primarily focuses on empathy.
LI Ying
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

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