Results 101 to 110 of about 4,260,477 (269)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Improving Patient Flow Through Axiomatic Design of Hospital Emergency Departments [PDF]

, 2009
Organised by: Cranfield UniversityIn response to crowding in hospital emergency departments (ED), efforts have been made to increase patient flow through the Fast Track (FT).
Kim, S-G., Peck, J.
core  

Digital immersive battle arena design

, 2021
LAUREA MAGISTRALECon lo sviluppo della comunicazione e delle tecnologie digitali e della rete 5G, sempre più settori come l'industria, l'istruzione, la medicina, i concerti e il gioco hanno maggiori opportunità di svilupparsi.
LIAO, YIWEI
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The Development of an On-Line Learning and Teaching Resource for the Socio-Centric Aspects of Sustainable Design

, 2009
This paper fits into the topics of socially relevant design, design and emotion and sustainable design and explores the question how can we create a more sustainable way of life?
Conrad, Franziska, Humphries-Smith, Tania   +1 more
core  

The effect of targeting both quantitative and qualitative objectives in generative design tools on the design outcomes

Current generative design tools backed by artificial intelligence (AI) primarily allow for quantitative inputs while qualitative aspects of a design, in particular aesthetics, have been shown to be considered indirectly by designers.
Yang, Maria C., Saadi, Jana I., Chong, Leah   +2 more
core   +1 more source

Hybrid aerodynamic shape optimization of an undertray by using a novel parametric exponential–sigmoid diffuser design and adjoint-based full car simulation

Engineering Applications of Computational Fluid Mechanics
A proper undertray and diffuser design is critically important in racing car aerodynamics, since it can increase downforce with reduced drag by enhancing the ground effect.
J.-M. Lasso-Parera, F.-J. Granados-Ortiz, J. Ortega-Casanova   +2 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Identifying and evaluating parallel design activities using the design structure matrix

, 2005
This paper describes an approach based upon the Design Structure Matrix (DSM) for identifying, evaluating and optimising one aspect of CE: activity parallelism.
Whitfield, R.I., Duffy, A.H.B., Kortabarria, L.   +2 more
core  

TRANSFORM: a novel study design to evaluate the effect of everolimus on long-term outcomes after kidney transplantation

Open Access Journal of Clinical Trials, 2014
Julio Pascual,1 Titte R Srinivas,2 Steven Chadban,3 Franco Citterio,4 Federico Oppenheimer,5 Helio Tedesco,6 Mitchell L Henry,7 Christophe Legendre,8 Yoshihiko Watarai,9 Claudia Sommerer,10 Po-Chang Lee,11 J Mark Hexham,12 Gaohong Dong,12 Peter Bernhardt,
Pascual J, Srinivas TR, Chadban S, Citterio F, Oppenheimer F, Tedesco H, Henry ML, Legendre C, Watarai Y, Sommerer C, Lee PC, Hexham JM, Dong G, Bernhardt P, Vincenti F   +14 more
doaj