Results 91 to 100 of about 4,260,477 (269)

Design and competitive edge: A model for design management excellence in European SME's

, 2002
This article suggests to use the conceptual model of Michael Porter Value Chain in order to integrate all the variables that explain the mechanism of value creation through design.
Borja de Mozota, B
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Design for empowerment [PDF]

This track explores empowerment as the primary focus of design for social change, rather than merely a side effect or outcome of design activity.
Santamaria, Laura, Kuzmina, Ksenija
core   +1 more source

Designing by frontline tobacco-prevention practitioners: How can Design Thinking workshop affect the development of public health strategies?

, 2020
Design thinking features a distinct process for probing deep problems and ensuring that the right questions are being addressed and feasible solutions proposed.
Fu-Yu Lin, Min-yuan Ma, Ma, Min-yuan, Lin, Fu-Yu, Hsieh, Eric Chen-F, Eric Chen-F Hsieh   +5 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

ELearning and EMaking in Product Design Education

, 2014
Creating proactive learners in design education requires inspiring students to think for themselves, to look beyond the classroom and see the opportunities and challenges in the outside world.
Loy, Jennifer
core  

Collaborative Trust Networks in Engineering Design Adaptation [PDF]

, 2011
Within organisations, decision makers have to rely on collaboration with other actors from different disciplines working within highly dynamic and distributed associated networks of varying size and scales.
Caldwell, Nicholas, Clarkson, P John, Atkinson, SR, Clarkson, PJ, Atkinson, Simon Reay, Maier, AM, Maier, Anja, ,, Maier, Anja M., Caldwell, NHM   +9 more
core  

On the Specimen Design, Physical Properties and Geometry Effect on Heat Generation and Thermal Gradient in Ultrasonic Fatigue

Machines
Performing fatigue characterisation is often an expensive task, being both time consuming and expensive. Taking that into account, ultrasonic fatigue testing is an interesting solution, since it can be thousands of times faster than traditional ...
Felipe Klein Fiorentin, Rita Dantas, Jorge Wolfs Gil, Andrea Piga Carboni, Thiago Antonio Fiorentin, Abílio Manuel Pinho de Jesus   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Mini Review on the Effects of Experimental Design, Including Variations in Participant Baseline Performance, When Testing the Efficacy of Polyphenol Consumption to Enhance Mood and Cognitive Function in Humans from a New Researcher Perspective

Proceedings
This review discusses the implications, from a new researcher’s perspective, of variations in the design, dose and participant age group used and their subsequent effects on the cognitive performance and mood observed in studies investigating the effect ...
Duaa Altuwairki, Kirsten Brandt
doaj   +1 more source