Results 51 to 60 of about 1,013,397 (268)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A Systems Engineering Hackathon – A Methodology Involving Multiple Stakeholders to Progress Conceptual Design of a Complex Engineered Product

IEEE Access, 2018
This paper describes a novel hackathon-style system engineering process and its value as an agile approach to the rapid generation and development of early design concepts of complex engineered products-in this case a future aircraft.
S. Saravi, D. Joannou, R. S. Kalawsky, M. R. N. King, I. Marr, M. Hall, P. C. J. Wright, R. Ravindranath, A. Hill   +8 more
doaj   +1 more source

Flexible gypsum mould applied in the mechanical system for blank of grouted ceramic handicrafts based on the radial movement of the sphere and connection by the principle of six-point positioning

The Journal of Engineering, 2020
In order to solve the problems of low production efficiency, poor quality of blanks, high labour intensity and inability to meet the market demand with the manual gypsum mould, a novel design of the gypsum mould to be applied into the automatic ...
Gu Lizhi, Huang Ehui, Song Jinling, Xu Jianmin, Zeng Nianfu, Fang Yuhao, Sun Wei, Chen Zhenhua   +7 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

RE-DESIGNING THE LIBRARY FOR DESIGN ENGINEERING

Proceedings of the Canadian Engineering Education Association (CEEA), 2011
This paper relates our experience at the Engineering & Science Library at Queen’s University, melding Library resources into the design engineering curriculum in the Faculty of Applied Science. Effective library support of design engineering comprises people, curriculum, collections and assessment.
Murphy, Sharon, Saleh, Nasser
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Connecting through the reinforcement – design, testing and construction of a folded reinforced glass structure

Journal of Facade Design and Engineering, 2014
Corresponding author: Paulo L. Carvalho, School of Architecture, University of Minho, Campus de Azurém, Guimarães, Portugal. Tel.: +351 253 510 500; E-mail: paulo.carvalho@arquitectura.uminho.pt A reinforced glass folded structure has been developed ...
Paulo L. Carvalho, Paulo J. S. Cruz, Frederic A. Veer   +2 more
doaj  

Computer simulation method for moving trajectories of biological particles in rotating vertebral bodies

The Journal of Engineering, 2020
Biomass fuel production has a variety of methods, and the use of biomass cracking to produce biofuels is an advanced technology used in many countries. In the control of the biofuel production process, how to get the motion law of the heat carrier in the
Cong Ling Zhu, Chang Chang Li, Ye Ye Weng   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source