Results 101 to 110 of about 13,832,790 (340)

Design Thinking [PDF]

open access: yes, 2010
{Excerpt} In a world of continuous flux, where markets mature faster and everyone is affected by information overload, organizations regard innovation, including management innovation, as the prime driver of sustainable competitive advantage.
Serrat, Olivier
core   +1 more source

Listening to student voices through scenario design: Aligning learning.futures [PDF]

open access: yes, 2016
This paper explores the preferred learning futures of students at the University of Technology Sydney and the alignments of students’ preferred futures with policy changes. The aim of the paper is to describe a different approach to listening to students’
Crosby, AL, McKenzie, J
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Asking about the future : methodological insights from energy biographies [PDF]

open access: yes, 2015
Temporality is fundamental to qualitative longitudinal research, inherent in the design of returning to participants over time, often to explore moments of change.
Butler, Catherine   +5 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Designing in the Street: Innovation In-Situ [PDF]

open access: yes, 2009
This paper suggests that taking the design process into the field and constantly engaging with the site to observe, intervene, brainstorm, prototype and create fosters unique forms of inspiration and innovation.
March, Wendy, Raijmakers, Bas
core  

Designing Postdigital Futures: Which Designs? Whose Futures?

open access: yesPostdigital Science and Education, 2023
Felicitas Macgilchrist   +3 more
openaire   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

The art of creating futures - practical theology and a strategic research sensitivity for the future

open access: yesActa Theologica, 2014
This paper explores a futures perspective for practical theology. Although there are some examples of a future orientation, a systematic futures perspective has not been developed.
J. A. van den Berg, R. R. Ganzevoort
doaj   +1 more source

Co-Producing Social Futures Through Design Research [PDF]

open access: yes, 2016
A report resulting from the research project 'Developing Participation in Social Design: Prototyping Projects, Programmes and Policies' (ProtoPublics) commissioned by the Arts and Humanities Research Council.
Julier, Guy, Kimbell, Lucy
core   +2 more sources

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