Results 151 to 160 of about 149,310 (291)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The Dr. House Effect: Experts' Impoliteness Influences Persuasion. [PDF]

Psych J
Garcia-Marques T, Silva R, Loureiro F, Lapa A.   +3 more
europepmc   +1 more source

Design intent tool: User guide

, 2002
This database tool provides a structured approach to recording design decisions that impact a facility's design intent in areas such as energy efficiency.Owners and de signers alike can plan, monitor and verify that a facility's design intent is being met during each stage of the design process.
Mills, Evan, Abell, Daniel, Bell, Geoffrey, Faludi, Jeremy, Greenberg, Steve, Hitchcock, Rob, Piette, Mary Ann, Sartor, Dale, Stum, Karl   +8 more
openaire   +1 more source

Design Intent for CAD Modeling Features Using Boolean Operations [PDF]

, 2017
Chandrakant Sonawane, Ghadge Sujit
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Safeguarding the skilled trades: burnout, job satisfaction, and the risk of turnover in Ontario electricians. [PDF]

Npj Ment Health Res
Shahzad M, Ledo JM, Azarmi M, Bani-Fatemi A, Nowrouzi-Kia B.   +4 more
europepmc   +1 more source

Design with intent : a design pattern toolkit for environmental and social behaviour change

, 2013
Daniel Lockton
openalex   +1 more source

Communicating Design Intent Using Drawing and Text [PDF]

William P. McCarthy, Justin Matejka, Karl D. D. Willis, Judith E. Fan, Yewen Pu   +4 more
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Development and evaluation of a novel voice-enabled prototype to support consistent application of surgical safety checklists: a proof-of-concept study. [PDF]

Patient Saf Surg
Medroa PMI, Saltan M, Heining SM, Denecke K.   +3 more
europepmc   +1 more source