Results 171 to 180 of about 23,644,290 (315)

A gesture-free geometric approach for mid-air expression of design intent in 3D virtual pottery

Comput. Aided Des., 2015
Vinayak, K. Ramani
semanticscholar   +1 more source

Rural Clinical Training for Australian Medical Students: A Scoping Review of Rural Workforce Outcomes. [PDF]

Aust J Rural Health
Pillen H, Jones D, Gladman J, Walters L, Ivers R, Lane S, Hennessy A, Hou XY.   +7 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Accidental and Intentional Drug Poisoning Mortality in Older Adults in Spain: Nationwide Trends, 2001-2022. [PDF]

Mayo Clin Proc Innov Qual Outcomes
Donat M, Ramírez-Alcázar C, Giné F, Sordo L, Martínez Torre S, Belza MJ, Barrio G, Politi J.   +7 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Conversion-intent PD-1-based chemoimmunotherapy restores surgical feasibility in borderline resectable or unresectable non-head-and-neck cutaneous squamous cell carcinoma. [PDF]

Oncologist
Qian W, Jia D, Wu H, Zou H, Xu H, Li T.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Selective legibility: From material readout to machine agency. [PDF]

Innovation (Camb)
Chen B.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A Longitudinal Study of Psychosocial and Behavioral Adaptations to Continuous Community Violence in Culiacán, Sinaloa, México. [PDF]

Int J Environ Res Public Health
Rábago-Monzón ÁR, Alemán-Villa KM, Terán E, Magaña-Gómez JA, Picos-Cárdenas VJ, De la Herrán-Arita BK, Calderón-Zamora L, De la Herrán-Arita AK.   +7 more
europepmc   +1 more source