Results 161 to 170 of about 13,948,543 (335)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
This Gestalt artistic research paper explores intent based on the idea that all human acts of creation and communication has intent, conscious or unconscious.Part of the Gestalt research conducted at the Department of Game design at Campus Gotland ...
Sandberg, Leo
core +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Greater than the sum of our parts: The new division of labor in design with AI. [PDF]
PNAS NexusMenold J +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Treatment terminations during radiation therapy: A retrospective descriptive single-center analysis. [PDF]
PLoS OneOzen A +7 more
europepmc +1 more source
Strategies for teaching sustainable design practice with product design students
, 2008 Teaching students how to tackle the issu e of producing practical, commercial product designs that respond to the sustainability impe rative is an important challenge for design educators at this time.
Loy, Jennifer
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
SAC-Optimized Fuzzy Variable Admittance Control for Lead-Through Teaching of Collaborative Robots. [PDF]
Sensors (Basel)Song Y, Ma G.
europepmc +1 more source
, 2010 Software used by architectural and industrial designers has shifted from becoming a tool for drafting, towards use in verification, simulation, project management and remote project sharing.
J. Burry +7 more
core