Results 191 to 200 of about 149,310 (291)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Applying Design Thinking for Co-Designed Health Solutions: A Case Study on Chronic Kidney Disease in Regional Australia. [PDF]

Int J Environ Res Public Health
Stefoska-Needham A, Nealon J, Charlton K, Fildes K, Lambert K.   +4 more
europepmc   +1 more source

Smart Color Palette Suggestions Based on Intent, Audience, and Design Context

Samruddhi Milind Save
openalex   +1 more source

Influence Factors of Intent to Purchase Personalized Controller Product Design in 3D Printing Environment

, 2020
Jun Hong Park, Jun Sang Lee
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Conveying organic character with a label: the role of color in the packaging of organic yogurt. [PDF]

J Sci Food Agric
Hernández B, Elso P, Sáenz C, Marín-Arroyo MR.   +3 more
europepmc   +1 more source

A design intent information model to support engineering design.

, 2004
Adrian Espinosa Bautista
openalex   +1 more source

Reflecting on Reggio: An evaluation of design intent in an early childhood learning environment [PDF]

, 2014
Hannah You, Lindy Osborne, Jill Franz
openalex  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

An intent-driven paradigm for feature-based design

, 1999
Marcelo da Silva Hounsell, Keith Case
openalex   +1 more source