Results 1 to 10 of about 2,087,196 (218)

Knowledge engineering in design [PDF]

Computer-Aided Design, 1988
The authors present, in a unifying framework, the principles of the IIICAD system, a generic design apprentice currently under development at CWI. IIICAD incorporates three kinds of design knowledge. First, it has general knowledge about the stepwise nature of design based on a set-theoretic design theory.
Varol Akman, Paul J. W. ten Hagen, Jan Rogier, Paul Veerkamp   +3 more
openaire   +1 more source

Knowledge Modeling for Eco-design [PDF]

Concurrent Engineering, 2007
The present major concern on sustainable development is at the beginning of a growing interest on product recyclability. More and more strict norms and regulations will be prescribed to companies in order to increase the level of recyclability of industrial products.
Raymond Houé, Bernard Grabot
openaire   +4 more sources

The interior design of [free] knowledge [PDF]

Journal of Cultural Economy, 2014
Peer ...
Corsín Jiménez, Alberto, Estalella, Adolfo, Zoohaus   +2 more
openaire   +2 more sources

Conceptualizing Design Knowledge in IS Research – A Review and Taxonomy of Design Knowledge Properties [PDF]

Proceedings of the Annual Hawaii International Conference on System Sciences, 2022
Design science projects are of great interest in information systems (IS) research. Typically, design-oriented projects generate valuable design knowledge through the design and possible instantiation of artifacts. Although designing novel artifacts and accumulating design knowledge is common practice in IS, there is still limited shared knowledge ...
Dickhaut, Ernestine, Janson, Andreas, Leimeister, Jan Marco   +2 more
openaire   +4 more sources

Knowledge-Design: Pushing the Limit of Protein Design via Knowledge Refinement

CoRR, 2023
Recent studies have shown competitive performance in protein design that aims to find the amino acid sequence folding into the desired structure. However, most of them disregard the importance of predictive confidence, fail to cover the vast protein space, and do not incorporate common protein knowledge. After witnessing the great success of pretrained
Zhangyang Gao, Cheng Tan 0012, Stan Z. Li   +2 more
openaire   +2 more sources

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Improved Early Referral in Long‐Term Survivor Care With Institutional Standardized Practice Among Childhood Leukemia Survivors#

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In 2018, the Texas Children's Cancer and Hematology Center Leukemia Program implemented a practice standard to support the transition from treatment to survivorship that includes shared, alternating care between leukemia and survivorship clinicians and a reminder to refer survivors to the long‐term survivor clinic (LTSC) 2 years after ...
Ji Yun Tark, Kayla L. Foster, Omar Shakeel, Mary C. Shapiro, Shawki L. Qasim, ZoAnn Dreyer, Eric S. Schafer, Ashley M. Butler, Austin L. Brown, Maria Monica Gramatges   +9 more
wiley   +1 more source

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

Health Literacy, Self‐Efficacy and Knowledge of Sickle Cell Disease Among Caregivers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a hereditary blood disorder in which abnormal haemoglobin leads to severe anaemia, painful crises and organ failure. Caregivers’ health literacy (HL) – their ability to assess, understand and apply information, and interact with healthcare professionals – is crucial for managing children with SCD, yet ...
Melanie Bruinooge, Maite E. Houwing, Rowena L. Grohssteiner, Ferdows Atiq, Sonja A. M. C. Teuben, Mirjam P. Fransen, Marjon H. Cnossen   +6 more
wiley   +1 more source

Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte, Hannah Koch, Olivia A. Coughlin, Jillian R. Bouck, Allie Carter, Seethal A. Jacob   +5 more
wiley   +1 more source