Results 111 to 120 of about 7,219,960 (314)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Adaptation and implementation of a process of innovation and design within a SME [PDF]

, 2014
A design process is a sequence of design phases, starting with the design requirement and leading to a definition of one or several system architectures. For every design phase, various support tools and resolution methods are proposed in the literature.
AMMAR, Adel Amin, NADEAU, Jean-Pierre, SCARAVETTI, Dominique   +2 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Developing a Design-Led Approach for the Food-Energy-Water Nexus in Cities

Urban Planning, 2019
Urban communities are particularly vulnerable to the future demand for food, energy and water, and this vulnerability is further exacerbated by the onset of climate change at local. Solutions need to be found in urban spaces.
Wanglin Yan, Rob Roggema
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Machine learning-based identification and assessment of snow disaster risks using multi-source data: Insights from Fukui prefecture, Japan

Progress in Disaster Science
Understanding the driving factors behind snowstorm risk and their nonlinear effects is critical for developing effective response strategies. This study, focusing on the 2018 Fukui snowstorm in Japan, integrates multi-source data, including mobile GPS ...
Zhenyu Yang, Hideomi Gokon, Qing Yu
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Research and Development of Test Automation Maturity Model Building and Assessment Methods for E2E Testing

Software
Background: While several test-automation maturity models (e.g., CMMI, TMMi, TAIM) exist, none explicitly integrate ISO 9001-based quality management systems (QMS), leaving a gap for organizations that must align E2E test automation with formal quality ...
Daiju Kato, Ayane Mogi, Hiroshi Ishikawa, Yasufumi Takama   +3 more
doaj   +1 more source

Designing Knowledge Strategies

Proceedings of the International Conference on Business Excellence
Abstract The purpose of this paper is to analyze how managers should design the company’s knowledge strategies. That is a new dimension of knowledge management and it can be performed by using design thinking and the theory of knowledge fields and knowledge dynamics.
openaire   +1 more source

A knowledge-based system design/information tool [PDF]

The objective of this effort was to develop a Knowledge Capture System (KCS) for the Integrated Test Facility (ITF) at the Dryden Flight Research Facility (DFRF). The DFRF is a NASA Ames Research Center (ARC) facility. This system was used to capture the
Allen, James G., Sikora, Scott E.
core   +1 more source