Results 111 to 120 of about 7,304,657 (316)

Design Knowledge Collection by Modeling [PDF]

, 1998
Since design is a process in which designers use various kinds of knowledge and it is an open-ended problem, it is difficult to prepare all necessary knowledge before design. Also, due to advances of technology, design knowledge is largely fragmental and compartmentized. This makes the communication among design experts or design agents difficult.
Masaharu Yoshioka, T. Sekiya, Tetsuo Tomiyama   +2 more
openaire   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Perception and argumentation in the LK-99 superconductivity controversy: a sentiment and argument mining analysis

Scientific Reports
The announcement of LK-99 as a potential room-temperature, ambient-pressure superconductor sparked widespread debate across both traditional news outlets and social media platforms.
Eunhye Kim, Wei Luo, Hunkoog Jho
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Developing a Design-Led Approach for the Food-Energy-Water Nexus in Cities

Urban Planning, 2019
Urban communities are particularly vulnerable to the future demand for food, energy and water, and this vulnerability is further exacerbated by the onset of climate change at local. Solutions need to be found in urban spaces.
Wanglin Yan, Rob Roggema
doaj   +1 more source

Knowledge data discovery and data mining in a design environment [PDF]

, 2000
Designers, in the process of satisfying design requirements, generally encounter difficulties in, firstly, understanding the problem and secondly, finding a solution [Cross 1998].
Duffy, Alex, Haffey, Mark
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Machine learning-based identification and assessment of snow disaster risks using multi-source data: Insights from Fukui prefecture, Japan

Progress in Disaster Science
Understanding the driving factors behind snowstorm risk and their nonlinear effects is critical for developing effective response strategies. This study, focusing on the 2018 Fukui snowstorm in Japan, integrates multi-source data, including mobile GPS ...
Zhenyu Yang, Hideomi Gokon, Qing Yu
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source