Results 121 to 130 of about 7,219,960 (314)

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Satisfaction Evaluation and Typological Optimization of Traditional Village Human Settlements from the Perspective of Villager Participation: A Northeast China Case Study

Land
To address demand–supply mismatches in traditional village human settlements (TVHSs), this study builds on existing human settlement research by introducing cultural landscape theory and constructing a comprehensive framework that includes the hard ...
Huaizhi Qi, Hideaki Kanai, Fucun Cao
doaj   +1 more source

Design & knowledge modeling - Knowledge modeling as design

, 1993
The paper presents a cognitive analysis of design as a problem-solving activity. Design is characterized through results from empirical studies of various design tasks. Based on this characterization, it will be argued why and how knowledge modeling can be considered as a design task.
openaire   +1 more source

Modelling process knowledge in architectural design: A case-based approach [PDF]

, 1995
The paper presents on-going research aimed at the understanding and support of process knowledge in architectural design, from early and not sufficiently defined, to satisfactorily-defined phases.
Arlati, Ezio, Bottelli, Valeria, Fogh, Christian, Tirassa, Maurizio   +3 more
core  

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

A study of information & knowledge generated during engineering design meetings [PDF]

, 2007
During the design process, there is a wealth of information generated, and although it may not be obvious at the time, this information can be extremely useful at a later instance when it may be no longer available.
Conway, Alastair, Ion, William, Juster, Neal, Wodehouse, Andrew   +3 more
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Full circle: Balancing the knowledge equilibrium between newly-enrolled design students and their design school [PDF]

, 2011
In a relationship where one party has less knowledge than the other, research suggests that providing the former with more context specific knowledge can reduce the anxiety experienced by this party.
Ghassan, Aysar
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Assessment of visual problems after acquired brain injury: a survey of current practice in Danish hospitals

Journal of Rehabilitation Medicine
Objectives: To explore current hospital practice in relation to the assessment of vision problems in patients with acquired brain injury. Design: A survey study.
Trine Schow, Eike Ines Wehling, Helle K. Falkenberg, Anne Norup, Karin Spangsberg Kristensen   +4 more
doaj   +1 more source