Results 51 to 60 of about 17,541,500 (288)
Design for Disruption: Creating Anti-Fragile Urban Delta Landscapes
Urban Planning, 2019 In this article three different responses are taken as the starting point how different types of disruption could be dealt with. These responses—repair, bounce back and grow stronger—are combined with three disruptions (sea level rise, storm surge and ...
Rob Roggema
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
City of Flows: The Need for Design-Led Research to Urban Metabolism
Urban Planning, 2019 The design of cities has long ignored the flows that shape the city. Water has been the most visible one, but energy and materials were invisible and/or taken for granted.
Rob Roggema
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Perspective: the gist of public tender for service design [PDF]
, 2018 Governments around the world are increasingly formalising design as an innovative approach to renew public services. In this development, the capabilities of external service design consultancies often play an important part, which calls for new insights
Person, Oscar +3 more
core +1 more source
Integrating inquiry-based learning into architectural design studios: toward a flexible framework
Journal of Asian Architecture and Building EngineeringSince the 2010s, architectural education has faced increasing criticism, highlighting the marginalization of research and theoretical inquiry within design studios dominated by visual and representational approaches.
Neslinur Hızlı Erkılıç
doaj +1 more source
Research on the Transformation of User's Implicit Knowledge to Design Knowledge in Product Design
Indonesian Journal of Electrical Engineering and Computer Science, 2017 The characteristics of the user’s implicit knowledge in product design and the relationship between the user’s implicit knowledge and design knowledge are discussed. The transformation model of user implicit knowledge to design knowledge is built. And the key technologies of it are analyzed. The four design dimensions which the transformation from user
Sun Qiang, Hu Fei
openaire +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design ScienceEarly robust design (RD) can lead to significant cost savings in the later stages of product development. In order to design systems that are insensitive to various sources of deviation in the early stages, specific design knowledge (SDK) plays a crucial
Jiahang Li +5 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source