Results 71 to 80 of about 7,219,960 (314)
Exploring Standards of Rigour for Design Cases [PDF]
, 2009 Designers share their specialized knowledge by developing design cases, which we define as representations of design efforts and outcomes disseminated to peers. In the field of instructional design this practice is not well established. In addition, many
Boling, Elizabeth, Smith, Kennon M
core
Representing and Capturing the Experts´ Knowledge in a Design Process [PDF]
, 2003 An object-oriented framework to support the modeling and management of the design process is introduced. It naturally integrates the representation of both the design process itself, and the outcomes that are achieved as the result of the various design ...
Gonnet, Silvio Miguel +2 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Cutting Cubes Out of Fog: The Whole View of Design
She Ji: The Journal of Design, Economics and Innovation, 2020 In this article we argue that the field of design evolved to include helping organizations address complex problems in the face of uncertainty, but it has yet to build knowledge in a way that formalizes the various activities embraced by the field.
Patrick Whitney, André Nogueira
doaj +1 more source
Capturing design knowledge [PDF]
A scheme is proposed to capture the design knowledge of a complex object including functional, structural, performance, and other constraints. Further, the proposed scheme is also capable of capturing the rationale behind the design of an object as a ...
Babin, Brian A., Loganantharaj, Rasiah
core +1 more source
Designing for mathematical abstraction [PDF]
, 2010 Our focus is on the design of systems (pedagogical, technical, social) that encourage mathematical abstraction, a process we refer to as designing for abstraction.
Noss, Richard, Pratt, Dave
core +3 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The prescriptive quality of 11 design principles for knowledge productivity [PDF]
, 2008 This study explores the learning processes that contribute to knowledge productivity: gradual improvement and radical innovation of an organisation’s operating procedures, products, and services, based on the development and application of new knowledge.
Kessels, Joseph W.M. +1 more
core +1 more source
A knowledge-based system with learning for computer communication network design [PDF]
, 1990 Computer communication network design is well-known as complex and hard. For that reason, the most effective methods used to solve it are heuristic. Weaknesses of these techniques are listed and a new approach based on artificial intelligence for solving
Hoang, Hai Hoc +2 more
core +2 more sources
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source